PMID- 31540313
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 10
IP  - 9
DP  - 2019 Sep 13
TI  - HLA-DQB1 and HLA-DRB1 Variants Confer Susceptibility to Latent Autoimmune 
      Diabetes in Adults: Relative Predispositional Effects among Allele Groups.
LID - 10.3390/genes10090710 [doi]
LID - 710
AB  - Latent autoimmune diabetes in adults (LADA) was recently demonstrated to be the 
      most frequent form of adult-onset autoimmune diabetes mellitus. Case-control 
      studies have investigated the relationship between human leukocyte antigen 
      (HLA)-DQB1 and HLA-DRB1 polymorphisms and LADA risk, but their conclusions are 
      inconsistent. This study aimed to more precisely explore the correlation between 
      these HLA gene variants and LADA development. Eight databases, including PubMed, 
      Embase, and Medline, were systematically searched for relevant studies up to 
      September 15, 2018. We performed this retrospective study using meta-analysis and 
      relative predispositional effect (RPE) methods. The meta-analysis results 
      indicated that DQB1*02 (odds ratio (OR) = 1.685, p(c) < 0.005) and DQB1*06 (OR = 
      0.604, p(c) = 0.010) have opposite effects on susceptibility to LADA, while a 
      significant decrease in LADA risk caused by DQB1*05 (OR = 0.764, p(c) = 0.100) 
      disappeared upon Bonferroni correction. The RPE method confirmed the roles of 
      DQB1*02 (chi(2) = 46.475, p < 0.001) and DQB1*06 (chi(2) = 17.883, p < 0.001) and further 
      suggested protective effects of DQB1*05 (chi(2) = 16.496, p < 0.001). Additionally, 
      the meta-analysis results showed that DRB1*03 (OR = 2.685, p(c) < 0.013), DRB1*04 
      (OR = 1.954, p(c) < 0.013), and DRB1*09 (OR = 1.346, p(c) < 0.013) are associated 
      with increased LADA risk, while DRB1*12 (OR = 0.600, p(c) < 0.013) and DRB1*13 
      (OR = 0.583, p(c) < 0.013) carriers have a decreased risk of developing LADA. 
      Furthermore, the RPE method revealed that DRB1*03 (chi(2) = 98.754, p < 0.001), 
      DRB1*04 (chi(2) = 94.685, p < 0.001), DRB1*09 (chi(2) = 40.489, p < 0.001), DRB1*01 (chi(2) = 
      12.181, p < 0.001), DRB1*07 (chi(2) = 10.882, p = 0.001), and DRB1*08 (chi(2) = 5.000, p 
      = 0.025) play protective roles against LADA. LADA showed a close relationship 
      with genetic polymorphisms of HLA-DQB1 and WHLA-DRB1, which could contribute to a 
      better understanding of disease pathogenesis and the identification of 
      predisposing loci in the diagnosis and treatment of LADA.
FAU - Zhang, Minting
AU  - Zhang M
AD  - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan 
      Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 
      523808, China. hjzxzmt@163.com.
AD  - The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, 
      Guangdong 523808, China. hjzxzmt@163.com.
FAU - Lin, Shuhuang
AU  - Lin S
AD  - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan 
      Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 
      523808, China. shuhuang_lin@yahoo.com.
AD  - The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, 
      Guangdong 523808, China. shuhuang_lin@yahoo.com.
FAU - Yuan, Xiaoling
AU  - Yuan X
AD  - School of Public Health, Guangdong Medical University, Dongguan, Guangdong 
      523808, China. 15622906467@163.com.
FAU - Lin, Ziqi
AU  - Lin Z
AD  - School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, 
      China. 15119054738@139.com.
FAU - Huang, Zunnan
AU  - Huang Z
AD  - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan 
      Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong 
      523808, China. zn_huang@yahoo.com.
AD  - Institute of Marine Biomedical Research, Guangdong Medical University, Zhanjiang, 
      Guangdong 524023, China. zn_huang@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20190913
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
PMC - PMC6771152
OTO - NOTNLM
OT  - DQB1
OT  - DRB1
OT  - human leukocyte antigen
OT  - latent autoimmune diabetes in adults
OT  - meta-analysis
OT  - polymorphisms
OT  - relative predispositional effects
COIS- The authors declare no conflicts of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of the data; 
      in the writing of the manuscript; or in the decision to publish the results.
EDAT- 2019/09/22 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/09/01
CRDT- 2019/09/22 06:00
PHST- 2019/06/17 00:00 [received]
PHST- 2019/09/03 00:00 [revised]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/09/22 06:00 [entrez]
PHST- 2019/09/22 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - genes10090710 [pii]
AID - genes-10-00710 [pii]
AID - 10.3390/genes10090710 [doi]
PST - epublish
SO  - Genes (Basel). 2019 Sep 13;10(9):710. doi: 10.3390/genes10090710.