PMID- 31540771
OWN - NLM
STAT- MEDLINE
DCOM- 20200325
LR  - 20200325
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 215
IP  - 11
DP  - 2019 Nov
TI  - miR-182 contributes to cell adhesion-mediated drug resistance in multiple myeloma 
      via targeting PDCD4.
PG  - 152603
LID - S0344-0338(19)31158-6 [pii]
LID - 10.1016/j.prp.2019.152603 [doi]
AB  - miR-182 is a well-described oncogenic miRNA playing a crucial role in the 
      development of many malignancies. However, the role of miR-182 in multiple 
      myeloma (MM) remains unclear. Here, we demonstrate that adhesion of H929 and 
      MM.1S cells to fibronectin could induce miR-182 expression and decrease PDCD4 
      expression. Furthermore, miR-182 was found to negatively regulate PDCD4 
      expression in H929 and MM.1S cells. In addition, PDCD4 down-regulation was 
      required for cell adhesion-mediated drug resistance (CAM-DR). Intriguingly, 
      miR-182 up-regulation could promote CAM-DR in H929 and MM.1S cells. Moreover, 
      miR-182 up-regulation and PDCD4 down-regulation enhanced AKT phosphorylation at 
      Ser473 in both H929 and MM.1S cells. Our data suggest that cell adhesion-mediated 
      miR-182 up-regulation and PDCD4 down-regulation may confer drug resistance via 
      enhancing AKT phosphorylation at Ser473.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Wu, Yaxun
AU  - Wu Y
AD  - Department of Pathology, Affiliated Tumor Hospital of Nantong University, 
      Nantong, 226361, Jiangsu, China.
FAU - Zhu, Xinghua
AU  - Zhu X
AD  - Department of Pathology, Affiliated Tumor Hospital of Nantong University, 
      Nantong, 226361, Jiangsu, China.
FAU - Shen, Rong
AU  - Shen R
AD  - Department of Pathology, Affiliated Tumor Hospital of Nantong University, 
      Nantong, 226361, Jiangsu, China.
FAU - Huang, Jieyu
AU  - Huang J
AD  - Department of Pathology, Affiliated Tumor Hospital of Nantong University, 
      Nantong, 226361, Jiangsu, China.
FAU - Xu, Xiaohong
AU  - Xu X
AD  - Department of Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, 
      226361, Jiangsu, China. Electronic address: xuxiaohongnantong@126.com.
FAU - He, Song
AU  - He S
AD  - Department of Pathology, Affiliated Tumor Hospital of Nantong University, 
      Nantong, 226361, Jiangsu, China. Electronic address: ntzlyyhesong515@ntu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190817
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn182 microRNA, human)
RN  - 0 (PDCD4 protein, human)
RN  - 0 (RNA-Binding Proteins)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Apoptosis Regulatory Proteins/*biosynthesis
MH  - Cell Adhesion/drug effects
MH  - Cell Line, Tumor
MH  - Drug Resistance, Neoplasm/*genetics
MH  - Gene Expression Regulation, Neoplastic/*genetics
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Multiple Myeloma/genetics/*pathology
MH  - Proto-Oncogene Proteins c-akt/biosynthesis
MH  - RNA-Binding Proteins/*biosynthesis
OTO - NOTNLM
OT  - Cell adhesion-mediated drug resistance
OT  - Multiple myeloma
OT  - Programmed cell death 4
OT  - miR-182
EDAT- 2019/09/22 06:00
MHDA- 2020/03/26 06:00
CRDT- 2019/09/22 06:00
PHST- 2019/06/10 00:00 [received]
PHST- 2019/08/01 00:00 [revised]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/09/22 06:00 [pubmed]
PHST- 2020/03/26 06:00 [medline]
PHST- 2019/09/22 06:00 [entrez]
AID - S0344-0338(19)31158-6 [pii]
AID - 10.1016/j.prp.2019.152603 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2019 Nov;215(11):152603. doi: 10.1016/j.prp.2019.152603. Epub 
      2019 Aug 17.