PMID- 31540775 OWN - NLM STAT- MEDLINE DCOM- 20210816 LR - 20210816 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 39 IP - 7 DP - 2020 Jul TI - Association between plasma strontium, a bone-seeking element, and type 2 diabetes mellitus. PG - 2151-2157 LID - S0261-5614(19)33045-6 [pii] LID - 10.1016/j.clnu.2019.08.033 [doi] AB - BACKGROUND & AIMS: Drinking water and food are the major sources of strontium in human. Strontium is essential for bone metabolism, while its role in glucose and lipid metabolism is largely unknown. We aimed to investigate the association of strontium, a bone-seeking element, with type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR) and to further explore the potential mechanisms. METHODS: The case-control study included 1448 newly diagnosed T2DM patients, 782 IGR patients, and 2230 matched controls with normal glucose tolerance. Plasma strontium and other plasma minerals were quantified via inductively coupled plasma mass spectrometry. Multivariable logistic regression analysis was used to evaluate the independent associations between plasma strontium and T2DM and IGR. RESULTS: Plasma strontium was inversely associated with T2DM and IGR. After adjustment for sociodemographic, lifestyle factors, and multiple plasma metals, the odds ratios (95% confidence intervals) of T2DM and IGR were 0.45 (0.35-0.57) and 0.55 (0.43-0.71), respectively, comparing the highest to the lowest quartile of plasma strontium levels. In spline analysis, the odds of T2DM and IGR decreased remarkably with increasing strontium concentration and followed by a plateau. Additionally, plasma strontium was negatively associated with total cholesterol, low density lipoprotein cholesterol, and lipid peroxidation (plasma malondialdehyde level). CONCLUSIONS: The current study indicated that higher plasma strontium concentration was associated with lower odds of T2DM and IGR. Further studies are warranted to confirm these findings and to clarify the underlying mechanisms. CI - Copyright (c) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. FAU - Chen, Liangkai AU - Chen L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Guo, Qianqian AU - Guo Q AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Qiang AU - Wang Q AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Luo, Cheng AU - Luo C AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Chen, Sijing AU - Chen S AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wen, Sheng AU - Wen S AD - Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. FAU - Tan, Aijun AU - Tan A AD - Zhuhai Center for Disease Control and Prevention, Zhuhai, China. FAU - Yang, Wei AU - Yang W AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Bao, Wei AU - Bao W AD - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA. FAU - Hu, Frank B AU - Hu FB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: frank.hu@channing.harvard.edu. FAU - Liu, Liegang AU - Liu L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: lgliu@mails.tjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190910 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - SY7Q814VUP (Calcium) RN - YZS2RPE8LE (Strontium) SB - IM MH - Adult MH - Biomarkers MH - Blood Glucose/*metabolism MH - *Bone Remodeling MH - Calcium/blood MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/*blood/diagnosis/prevention & control MH - Female MH - Glucose Intolerance/*blood/diagnosis/prevention & control MH - Humans MH - Male MH - Middle Aged MH - Risk Assessment MH - Risk Factors MH - Strontium/*blood OTO - NOTNLM OT - Calcium OT - Case-control study OT - Impaired glucose regulation OT - Strontium OT - Type 2 diabetes mellitus EDAT- 2019/09/22 06:00 MHDA- 2021/08/17 06:00 CRDT- 2019/09/22 06:00 PHST- 2019/05/02 00:00 [received] PHST- 2019/08/14 00:00 [revised] PHST- 2019/08/29 00:00 [accepted] PHST- 2019/09/22 06:00 [pubmed] PHST- 2021/08/17 06:00 [medline] PHST- 2019/09/22 06:00 [entrez] AID - S0261-5614(19)33045-6 [pii] AID - 10.1016/j.clnu.2019.08.033 [doi] PST - ppublish SO - Clin Nutr. 2020 Jul;39(7):2151-2157. doi: 10.1016/j.clnu.2019.08.033. Epub 2019 Sep 10.