PMID- 31541695
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20231027
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 75
DP  - 2019 Dec
TI  - Sex-specific behavioral effects following developmental exposure to 
      tetrabromobisphenol A (TBBPA) in Wistar rats.
PG  - 136-147
LID - S0161-813X(19)30087-7 [pii]
LID - 10.1016/j.neuro.2019.09.003 [doi]
AB  - Tetrabromobisphenol A (TBBPA) has become a ubiquitous indoor contaminant due to 
      its widespread use as an additive flame retardant in consumer products. Reported 
      evidence of endocrine disruption and accumulation of TBBPA in brain tissue has 
      raised concerns regarding its potential effects on neurodevelopment and behavior. 
      The goal of the present study was to examine the impact of developmental TBBPA 
      exposure, across a wide range of doses, on sexually dimorphic non-reproductive 
      behaviors in male and female Wistar rats. We first ran a pilot study using a 
      single TBBPA dose hypothesized to produce behavioral effects. Wistar rat dams 
      were orally exposed using cookie treats to 0 or 0.1 mg TBBPA/kg bw daily from 
      gestational day (GD) 9 to postnatal day (PND) 21 to assess offspring (both sexes) 
      activity and anxiety-related behaviors. Significant effects were evident in 
      females, with exposure increasing activity levels. Thus, this dose was used as 
      the lowest TBBPA dose in a subsequent, larger study conducted as part of a 
      comprehensive assessment of TBBPA toxicity. Animals were exposed to 0, 0.1, 25, 
      or 250 mg TBBPA/kg bw daily by oral gavage starting on GD 6 through PND 90 (dosed 
      dams GD 6 - PND 21, dosed offspring PND 22 - PND 90). Significant behavioral 
      findings were observed for male offspring, with increased anxiety-like behavior 
      as the primary phenotype. These findings demonstrate that exposure to 
      environmental contaminants, like TBBPA, can have sex-specific effects on behavior 
      highlighting the vulnerability of the developing brain.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Rock, Kylie D
AU  - Rock KD
AD  - Department of Biological Sciences, North Carolina State University, Raleigh, NC, 
      27695, USA.
FAU - Gillera, Sagi Enicole A
AU  - Gillera SEA
AD  - Department of Biological Sciences, North Carolina State University, Raleigh, NC, 
      27695, USA; National Toxicology Program Laboratory, National Institute of 
      Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
FAU - Devarasetty, Pratyush
AU  - Devarasetty P
AD  - Department of Biological Sciences, North Carolina State University, Raleigh, NC, 
      27695, USA.
FAU - Horman, Brian
AU  - Horman B
AD  - Department of Biological Sciences, North Carolina State University, Raleigh, NC, 
      27695, USA.
FAU - Knudsen, Gabriel
AU  - Knudsen G
AD  - Laboratory of Toxicokinetics, National Cancer Institute, Research Triangle Park, 
      NC, 27709, USA.
FAU - Birnbaum, Linda S
AU  - Birnbaum LS
AD  - Laboratory of Toxicokinetics, National Cancer Institute, Research Triangle Park, 
      NC, 27709, USA.
FAU - Fenton, Suzanne E
AU  - Fenton SE
AD  - National Toxicology Program Laboratory, National Institute of Environmental 
      Health Sciences, Research Triangle Park, NC, 27709, USA.
FAU - Patisaul, Heather B
AU  - Patisaul HB
AD  - Department of Biological Sciences, North Carolina State University, Raleigh, NC, 
      27695, USA; Center for Human Health and the Environment, North Carolina State 
      University, Raleigh, NC, 27695, USA. Electronic address: hbpatisaul@ncsu.edu.
LA  - eng
GR  - T32 ES007046/ES/NIEHS NIH HHS/United States
GR  - P30 ES025128/ES/NIEHS NIH HHS/United States
GR  - T32 ES021432/ES/NIEHS NIH HHS/United States
GR  - ZIA ES102785-01/ImNIH/Intramural NIH HHS/United States
GR  - ZIA BC011476-01/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20190918
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Flame Retardants)
RN  - 0 (Polybrominated Biphenyls)
RN  - FQI02RFC3A (tetrabromobisphenol A)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Endocrine Disruptors/*toxicity
MH  - Flame Retardants/*toxicity
MH  - Maze Learning/drug effects
MH  - Motor Activity/drug effects
MH  - Polybrominated Biphenyls/*toxicity
MH  - Rats
MH  - Rats, Wistar/growth & development
MH  - Sex Factors
PMC - PMC6935469
MID - NIHMS1543755
OTO - NOTNLM
OT  - anxiety
OT  - brain
OT  - elevated plus maze
OT  - endocrine disruptions
OT  - flame retardants
OT  - hyperactivity
OT  - neural
OT  - neurodevelopment
OT  - neurotoxic
OT  - sex differences
OT  - sexually dimorphic
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2019/09/22 06:00
MHDA- 2020/05/01 06:00
PMCR- 2020/12/01
CRDT- 2019/09/22 06:00
PHST- 2019/06/06 00:00 [received]
PHST- 2019/08/07 00:00 [revised]
PHST- 2019/09/02 00:00 [accepted]
PHST- 2019/09/22 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/09/22 06:00 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S0161-813X(19)30087-7 [pii]
AID - 10.1016/j.neuro.2019.09.003 [doi]
PST - ppublish
SO  - Neurotoxicology. 2019 Dec;75:136-147. doi: 10.1016/j.neuro.2019.09.003. Epub 2019 
      Sep 18.