PMID- 31541887
OWN - NLM
STAT- MEDLINE
DCOM- 20200513
LR  - 20200513
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 120
DP  - 2019 Dec
TI  - The dual roles of autophagy in gliomagenesis and clinical therapy strategies 
      based on autophagic regulation mechanisms.
PG  - 109441
LID - S0753-3322(19)33501-2 [pii]
LID - 10.1016/j.biopha.2019.109441 [doi]
AB  - Autophagy, a self-digestion intracellular catabolic process, plays a crucial role 
      in cellular homeostasis under conditions of starvation, oxidative stress and 
      genotoxic stress. The capability of maintaining homeostasis contributes to 
      preventing malignant behavior in normal cells. Many studies have provided 
      compelling evidence that autophagy is involved in brain tumor recurrence and 
      chemotherapy and radiotherapy resistance. Gliomas, as the primary central nervous 
      system (CNS) tumors, are characterized by rapid, aggressive growth and recurrence 
      and have a poor prognosis and bleak outlook even with modern multimodality 
      strategies involving maximal surgical resection, radiotherapy and alkylating 
      agent-based chemotherapy. Autophagy-associated signaling pathways, such as the 
      extracellular signal-regulated kinase1/2 (ERK1/2) pathway, class I 
      phosphatidylinositol 3-phosphate kinase (PI3K)/AKT/mammalian target of rapamycin 
      (mTOR) pathway and nuclear factor kappa-B (NF-kappaB) pathway, act as tumor 
      suppressors or protect tumor cells against chemotherapy/radiotherapy-induced 
      cytotoxicity in gliomagenesis. Through these pathways, both lethal autophagy and 
      protective autophagy play crucial roles in tumor initiation, chemoresistance and 
      glioma stem cell differentiation. Moreover, lethal autophagy and protective 
      autophagy have been identified as novel therapeutic targets in glioma according 
      to the mechanisms described above. Here, we discuss the multiple impacts of the 
      autophagic response on distinct phases of gliomagenesis and the advanced progress 
      of therapies based on this concept.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Feng, Fan
AU  - Feng F
AD  - Institute of Clinical Medicine College, Qingdao University, # 38, Dengzhou Road, 
      Qingdao 266071, Shandong, China.
FAU - Zhang, Moxuan
AU  - Zhang M
AD  - Weifang Medical University, 261042, # 7166, Baotong Western Road, Weifang, 
      Shandong, China.
FAU - Yang, Chuanchao
AU  - Yang C
AD  - Weifang Medical University, 261042, # 7166, Baotong Western Road, Weifang, 
      Shandong, China.
FAU - Heng, Xueyuan
AU  - Heng X
AD  - Department of Neurosurgery, Linyi People's Hospital, # 27, Jiefang Eastern Road, 
      Linyi 276000, Shandong, China. Electronic address: hengxuey001@163.com.
FAU - Wu, Xiujie
AU  - Wu X
AD  - Department of Neurosurgery, Linyi People's Hospital, # 27, Jiefang Eastern Road, 
      Linyi 276000, Shandong, China. Electronic address: wuxiuj001@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190918
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Animals
MH  - Autophagy/*physiology
MH  - Brain Neoplasms/metabolism/physiopathology
MH  - Central Nervous System Neoplasms/metabolism/physiopathology
MH  - Glioblastoma
MH  - Glioma/*metabolism/*physiopathology
MH  - Humans
MH  - Neoplasm Recurrence, Local/physiopathology
MH  - Signal Transduction
OTO - NOTNLM
OT  - Autophagy
OT  - Clinical therapy
OT  - GSCs
OT  - Gliomas
OT  - Signaling pathway
EDAT- 2019/09/22 06:00
MHDA- 2020/05/14 06:00
CRDT- 2019/09/22 06:00
PHST- 2019/07/18 00:00 [received]
PHST- 2019/09/02 00:00 [revised]
PHST- 2019/09/06 00:00 [accepted]
PHST- 2019/09/22 06:00 [pubmed]
PHST- 2020/05/14 06:00 [medline]
PHST- 2019/09/22 06:00 [entrez]
AID - S0753-3322(19)33501-2 [pii]
AID - 10.1016/j.biopha.2019.109441 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2019 Dec;120:109441. doi: 10.1016/j.biopha.2019.109441. Epub 
      2019 Sep 18.