PMID- 31541983
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 130
IP  - 11
DP  - 2019 Nov
TI  - Diagnostic yield of high-density versus low-density EEG: The effect of spatial 
      sampling, timing and duration of recording.
PG  - 2060-2064
LID - S1388-2457(19)31193-9 [pii]
LID - 10.1016/j.clinph.2019.08.007 [doi]
AB  - OBJECTIVE: To investigate the effect of spatial sampling and of recording 
      duration on the diagnostic yield of EEG for identification of interictal 
      epileptiform discharges (IEDs). Previous studies demonstrated that high-density 
      (HD) recordings increased accuracy of localization compared to low-density (LD) 
      recordings. METHODS: We have prospectively evaluated the effect of spatial 
      sampling and of recording duration in patients who had short-term (ST) recordings 
      with a HD array of 256 electrodes following long-term (LT) recordings with a LD 
      array consisting of the standard IFCN array of 25 electrodes. IED clusters were 
      identified in four datasets: LT-LD, ST-LD (spatially down-sampled to the standard 
      IFCN array), ST-HD and a shortened (90 minutes) epoch of LT-LD. RESULTS: Sixty 
      consecutive patients were recruited. We identified 89 IED clusters totally. Two 
      clusters were found by increasing spatial sampling from 25 to 256 electrodes. 
      This modest increase was not statistically significant. Eight clusters were 
      missed by reducing the recording duration to 90 minutes, as compared with the LT 
      recordings (p = 0.003). CONCLUSIONS: Recording duration is more important for the 
      diagnostic yield of EEGs than increasing spatial sampling beyond the standard 
      IFCN electrode array. SIGNIFICANCE: The standard IFCN electrode array provides 
      sufficient spatial sampling for identification of the IEDs.
CI  - Copyright (c) 2019 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Bach Justesen, Anders
AU  - Bach Justesen A
AD  - Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, 
      Denmark.
FAU - Foged, Mette Thrane
AU  - Foged MT
AD  - Neurobiology Research Unit, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Fabricius, Martin
AU  - Fabricius M
AD  - Department of Clinical Neurophysiology, Copenhagen University Hospital, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Skaarup, Christian
AU  - Skaarup C
AD  - Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, 
      Denmark.
FAU - Hamrouni, Nizar
AU  - Hamrouni N
AD  - Neurobiology Research Unit, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Copenhagen, Denmark.
FAU - Martens, Terje
AU  - Martens T
AD  - Neurobiology Research Unit, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Copenhagen, Denmark.
FAU - Paulson, Olaf B
AU  - Paulson OB
AD  - Neurobiology Research Unit, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Pinborg, Lars H
AU  - Pinborg LH
AD  - Neurobiology Research Unit, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, 
      University of Copenhagen, Copenhagen, Denmark; Epilepsy Clinic, Department of 
      Neurology Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
FAU - Beniczky, Sandor
AU  - Beniczky S
AD  - Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, 
      Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 
      Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark. Electronic address: sbz@filadelfia.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190822
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiopathology
MH  - Child
MH  - *Electroencephalography
MH  - Epilepsy/*diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Seizures/*diagnosis/physiopathology
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - Diagnostic yield
OT  - Duration
OT  - EEG
OT  - High-density array
OT  - Interictal epileptiform discharges
OT  - Spatial sampling
EDAT- 2019/09/22 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/09/22 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/07/31 00:00 [revised]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2019/09/22 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/09/22 06:00 [entrez]
AID - S1388-2457(19)31193-9 [pii]
AID - 10.1016/j.clinph.2019.08.007 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2019 Nov;130(11):2060-2064. doi: 10.1016/j.clinph.2019.08.007. 
      Epub 2019 Aug 22.