PMID- 31544528
OWN - NLM
STAT- MEDLINE
DCOM- 20200409
LR  - 20200409
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 33
IP  - 6
DP  - 2019 Dec
TI  - Impact of transsphenoidal surgery for pituitary adenomas on overall 
      health-related quality of life: a longitudinal cohort study.
PG  - 635-640
LID - 10.1080/02688697.2019.1667480 [doi]
AB  - Background: Previous studies show a moderate improvement in health-related 
      quality of life (HRQoL) following transsphenoidal surgery for pituitary adenomas, 
      but no consistent predictors of HRQoL outcome have been identified. We aimed to 
      evaluate overall HRQoL changes following such surgery, and assess potential 
      patient or tumour characteristics that predict HRQoL outcome.Materials and 
      methods: Sixty adult patients undergoing transsphenoidal resection of pituitary 
      adenomas were prospectively enrolled. They completed the EQ-5D 3L, a generic 
      HRQoL questionnaire, preoperatively, and at one (n = 57) and six months (n = 56) 
      postoperatively. HRQoL was assessed as both postoperative change in median EQ-5D 
      3L score, and as change greater than the minimal clinically important difference 
      (MCID) in EQ-5D 3L score. A multivariable logistic regression analysis was 
      performed to assess potential predictors of clinically significant HRQoL changes 
      (>MCID) at six months postoperatively.Results: There was a slight, but 
      statistically significant, improvement in median EQ-5D 3L scores at six months 
      postoperatively compared to preoperatively. Sixteen patients (29%) reported a 
      clinically significant improvement in HRQoL at six months postoperatively, and 
      larger preoperative tumour volume was a statistically significant predictor of 
      such improvement. Eight patients (14%) reported a clinically significant 
      deterioration in HRQoL at six months, but none of the assessed variables 
      predicted such deterioration.Conclusions: Patient-reported overall HRQoL improved 
      slightly after transsphenoidal surgery for pituitary adenomas at group level. 
      Patients with larger tumours might have more HRQoL benefits from surgery, but the 
      mechanisms behind the predictive nature of tumour volume remain unknown.
FAU - Sommerfelt, Hanne
AU  - Sommerfelt H
AUID- ORCID: 0000-0001-5068-6029
AD  - Department of Neuromedicine and Movement Science, NTNU, Norwegian University of 
      Science and Technology, Trondheim, Norway.
FAU - Sagberg, Lisa Millgard
AU  - Sagberg LM
AD  - Department of Neuromedicine and Movement Science, NTNU, Norwegian University of 
      Science and Technology, Trondheim, Norway.
AD  - Department of Neurosurgery, St. Olav s University Hospital, Trondheim, Norway.
AD  - Norwegian National Advisory Unit for Ultrasound and Image-Guided Therapy, St. 
      Olav s University Hospital, Trondheim, Norway.
FAU - Solheim, Ole
AU  - Solheim O
AD  - Department of Neuromedicine and Movement Science, NTNU, Norwegian University of 
      Science and Technology, Trondheim, Norway.
AD  - Department of Neurosurgery, St. Olav s University Hospital, Trondheim, Norway.
AD  - Norwegian National Advisory Unit for Ultrasound and Image-Guided Therapy, St. 
      Olav s University Hospital, Trondheim, Norway.
LA  - eng
PT  - Journal Article
DEP - 20190922
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Adenoma/*surgery
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/adverse effects/*methods
MH  - Pituitary Neoplasms/*surgery
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Quality of Life
MH  - Sphenoid Bone/*surgery
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Patient-reported outcome measures
OT  - pituitary adenoma
OT  - pituitary surgery
OT  - quality of life
EDAT- 2019/09/24 06:00
MHDA- 2020/04/10 06:00
CRDT- 2019/09/24 06:00
PHST- 2019/09/24 06:00 [pubmed]
PHST- 2020/04/10 06:00 [medline]
PHST- 2019/09/24 06:00 [entrez]
AID - 10.1080/02688697.2019.1667480 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2019 Dec;33(6):635-640. doi: 10.1080/02688697.2019.1667480. Epub 
      2019 Sep 22.