PMID- 31544728
OWN - NLM
STAT- MEDLINE
DCOM- 20200605
LR  - 20221207
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 122
IP  - 8
DP  - 2019 Oct 28
TI  - Carbohydrate and sodium intake and physical activity interact with genetic risk 
      scores of four genetic variants mainly related to lipid metabolism to modulate 
      metabolic syndrome risk in Korean middle-aged adults.
PG  - 919-927
LID - 10.1017/S0007114519001752 [doi]
AB  - Metabolic syndrome (MetS) risk is influenced by genetic and environmental 
      factors. The present study explored genetic risk scores (GRS) of genetic variants 
      that influence the MetS and the effect of interactions between GRS and nutrient 
      intake on MetS risk. The genetic variants that influence MetS risk were selected 
      by genome-wide association study after adjusting for age, sex, area of residence 
      and BMI in 8840 middle-aged adults. GRS were calculated by summing the risk 
      alleles of the selected SNP and divided into low (0-1), medium (2-3) and high 
      (4-7) risk groups, and the relationships between the MetS and GRS were determined 
      by logistic regression after adjusting covariates involved in MetS risk. We also 
      analysed the interaction between GRS and lifestyles. Four genetic variants 
      (APOA5_rs651821, EFCAB4B_rs4766165, ZNF259_rs2160669 and APOBEC1_rs10845640) were 
      selected because they increased MetS risk after adjusting for covariates. 
      Individuals with medium-GRS and high-GRS alleles had a higher MetS risk by 1.48- 
      and 2.23-fold, respectively, compared with those with low-GRS after adjusting for 
      covariates. The increase in MetS risk was mainly related to serum TAG and 
      HDL-cholesterol concentrations. The GRS had an interaction with carbohydrate 
      (CHO) and Na intakes and daily physical activities for MetS risk. In conclusion, 
      Asian middle-aged adults with high-GRS alleles were at increased MetS risk mainly 
      due to dyslipidaemia. High daily physical activity (>/=1 h moderate activity per d) 
      reduced the MetS risk but a low-CHO diet (<65 % of total energy intake) increased 
      the risk in carriers with high-GRS alleles. Low Na intake (<1.6 g Na intake/4 MJ) 
      did not decrease its risk.
FAU - Zhou, Jun-Yu
AU  - Zhou JY
AD  - Department of Food and Nutrition, College of Life and Health Sciences, Hoseo 
      University, Asan, Chungnam 31499, Republic of Korea.
FAU - Song, Mi Young
AU  - Song MY
AD  - Department of Culinary Nutrition & Food Science, Woo Song University, Daejeon 
      34606, Republic of Korea.
FAU - Park, Sunmin
AU  - Park S
AD  - Department of Food and Nutrition, College of Life and Health Sciences, Hoseo 
      University, Asan, Chungnam 31499, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190923
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Sodium, Dietary)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Diet/adverse effects
MH  - Dietary Carbohydrates/*adverse effects
MH  - Energy Intake/*genetics
MH  - *Exercise
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Life Style
MH  - Lipid Metabolism/genetics
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Republic of Korea
MH  - Risk Factors
MH  - Sodium, Dietary/*adverse effects
OTO - NOTNLM
OT  - Dyslipidaemia
OT  - Genetic risk score
OT  - Lifestyles
OT  - Metabolic syndrome
OT  - Nutrients
OT  - SNP
EDAT- 2019/09/24 06:00
MHDA- 2020/06/06 06:00
CRDT- 2019/09/24 06:00
PHST- 2019/09/24 06:00 [pubmed]
PHST- 2020/06/06 06:00 [medline]
PHST- 2019/09/24 06:00 [entrez]
AID - S0007114519001752 [pii]
AID - 10.1017/S0007114519001752 [doi]
PST - ppublish
SO  - Br J Nutr. 2019 Oct 28;122(8):919-927. doi: 10.1017/S0007114519001752. Epub 2019 
      Sep 23.