PMID- 31545278
OWN - NLM
STAT- MEDLINE
DCOM- 20200204
LR  - 20200204
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 118
DP  - 2019 Oct
TI  - The renal protection of flavonoid-rich ethanolic extract from silkworm green 
      cocoon involves in inhibiting TNF-alpha-p38 MAP kinase signalling pathway in type 2 
      diabetic mice.
PG  - 109379
LID - S0753-3322(19)32835-5 [pii]
LID - 10.1016/j.biopha.2019.109379 [doi]
AB  - BACKGROUND: Diabetic nephropathy (DN) is one of the major complications of 
      diabetes. Sericin and flavonoids are two bioactive substances which have been 
      demonstrated to have some therapeutical effect on diabetic nephropathy. The aim 
      of this paper is to investigate the effect of ethanolic extract (EE) rich in 
      quercetin and kaempferol and their glucosides from the green cocoon of silkworm 
      Bombyx mori on DN in type 2 diabetic (T2D) mice induced by high-fat and 
      streptozotocin (STZ). METHODS: Ethanolic extract from the green cocoon shell of 
      silkworm Bombyx mori was used as material. Diabetic mice were orally treated with 
      three doses (150, 250 and 350 mg/kg) of the extract for 7 weeks, then the levels 
      of oxidases and related inflammatory factors were measured in kidneys. RESULTS: 
      Compared with the negative control, EE administration resulted in an evident 
      reduction in blood glucose levels and an improvement of the body weight in 
      diabetic mice. Oral EE could inhibit the expressions of renal tumour necrosis 
      factor TNF-alpha, monocyte chemoattractant protein-1 (MCP-1), fibronectin (FN) and 
      P38 mitogen-activated protein kinase (p38 MAPK) in T2D mice. Moreover, the levels 
      of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were 
      significantly elevated in T2D mice treated with EE. CONCLUSIONS: The activities 
      of anti-fibrosis and anti-inflammation contributed to the renal protective 
      effects by reducing oxidative stress, which might be mediated by the inhibition 
      of the TNF-alpha-p38 MAP kinase signalling pathway. It is suggested that the 
      ethanolic extract from silkworm green cocoon might be potential as an herbal 
      medicine for DN.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Wang, Hai-Yan
AU  - Wang HY
AD  - Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, 
      Soochow University, China.
FAU - Zhao, Jin-Ge
AU  - Zhao JG
AD  - Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, 
      Soochow University, China.
FAU - Wei, Zheng-Guo
AU  - Wei ZG
AD  - Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, 
      Soochow University, China. Electronic address: szwei2002@126.com.
FAU - Zhang, Yu-Qing
AU  - Zhang YQ
AD  - Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, 
      Soochow University, China. Electronic address: sericult@suda.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190828
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Fibronectins)
RN  - 0 (Flavonoids)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
RN  - 0 (Protective Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Bombyx
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/enzymology
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/enzymology
MH  - Ethanol/chemistry
MH  - Fasting/blood
MH  - Fibronectins/metabolism
MH  - Flavonoids/chemistry/pharmacology/*therapeutic use
MH  - Inflammation Mediators/metabolism
MH  - Kidney/drug effects/*pathology
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Mice, Inbred ICR
MH  - Plant Extracts/administration & dosage/pharmacology/*therapeutic use
MH  - Protective Agents/administration & dosage/pharmacology/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/*metabolism
OTO - NOTNLM
OT  - Antioxidase
OT  - Diabetic nephropathy
OT  - Ethanolic extract
OT  - Sericin
EDAT- 2019/09/24 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/09/24 06:00
PHST- 2019/06/13 00:00 [received]
PHST- 2019/08/16 00:00 [revised]
PHST- 2019/08/22 00:00 [accepted]
PHST- 2019/09/24 06:00 [entrez]
PHST- 2019/09/24 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - S0753-3322(19)32835-5 [pii]
AID - 10.1016/j.biopha.2019.109379 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2019 Oct;118:109379. doi: 10.1016/j.biopha.2019.109379. Epub 
      2019 Aug 28.