PMID- 31546293
OWN - NLM
STAT- MEDLINE
DCOM- 20200207
LR  - 20200207
IS  - 1738-8872 (Electronic)
IS  - 1017-7825 (Linking)
VI  - 29
IP  - 11
DP  - 2019 Nov 28
TI  - Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse 
      Splenocytes and Macrophages.
PG  - 1739-1744
LID - 10.4014/jmb.1812.12002 [doi]
AB  - The present study evaluates the immunomodulatory effect of Bifidobacterium longum 
      KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 
      regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-gamma)/Th2 
      (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, 
      immunoglobulin E (IgE) levels were significantly lower after treatment with B. 
      longum KACC 91563. These findings suggest that B. longum KACC 91563 could 
      modulate the systemic immune system toward both IgE production and regulation of 
      the Th1/Th2 balance.
FAU - Choi, Mijoo
AU  - Choi M
AD  - Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic 
      of Korea.
FAU - Lee, Yunjung
AU  - Lee Y
AD  - Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic 
      of Korea.
FAU - Lee, Na-Kyoung
AU  - Lee NK
AD  - Department of Food Science and Biotechnology of Animal Resources, Konkuk 
      University, Seoul 05029, Republic of Korea.
FAU - Bae, Chun Ho
AU  - Bae CH
AD  - Aram Co., Ltd., Gyeonggi-do 12735, Republic of Korea.
FAU - Park, Dae Chul
AU  - Park DC
AD  - Aram Co., Ltd., Gyeonggi-do 12735, Republic of Korea.
FAU - Paik, Hyun-Dong
AU  - Paik HD
AD  - Department of Food Science and Biotechnology of Animal Resources, Konkuk 
      University, Seoul 05029, Republic of Korea.
FAU - Park, Eunju
AU  - Park E
AD  - Department of Food and Nutrition, Kyungnam University, Changwon 51767, Republic 
      of Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Microbiol Biotechnol
JT  - Journal of microbiology and biotechnology
JID - 9431852
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Bifidobacterium longum/*immunology
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Immunoglobulin E/metabolism
MH  - *Immunomodulation
MH  - Lymphocytes/immunology
MH  - Macrophages/*immunology/microbiology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Spleen/cytology/*immunology/microbiology
MH  - Th1-Th2 Balance
OTO - NOTNLM
OT  - Bifidobacterium longum KACC 91563
OT  - Th1/Th2 balance
OT  - cytokine
OT  - immunomodulatory effect
EDAT- 2019/09/25 06:00
MHDA- 2020/02/08 06:00
CRDT- 2019/09/24 06:00
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2020/02/08 06:00 [medline]
PHST- 2019/09/24 06:00 [entrez]
AID - 10.4014/jmb.1812.12002 [pii]
AID - 10.4014/jmb.1812.12002 [doi]
PST - ppublish
SO  - J Microbiol Biotechnol. 2019 Nov 28;29(11):1739-1744. doi: 
      10.4014/jmb.1812.12002.