PMID- 315469
OWN - NLM
STAT- MEDLINE
DCOM- 19800119
LR  - 20041117
IS  - 0141-2760 (Print)
IS  - 0141-2760 (Linking)
VI  - 1
IP  - 3
DP  - 1978 Nov
TI  - Requirement of HLA compatibility between T- and B-cells in mitogen-induced in 
      vitro immunoglobulin production.
PG  - 245-8
AB  - The necessity for human leukocyte antigen (HLA) compatibility in T- and B-cells 
      in the differentiation of B-cells into immunoglobulin-producing cells (Ig cells) 
      was studied in cultured human lymphocytes stimulated with pokeweed mitogen. We 
      found that, despite the histocompatibility antigen difference, allogeneic T-cells 
      from healthy donors could help B-cells to differentiate into 
      immunoglobulin-producing cells to almost the same degree as autologous T-cells. 
      However, T-cells from an apparently healthy subject whose sister had died of 
      severe combined immunodeficiency did not collaborate with HLA-incompatible 
      allogeneic B-cells in vitro, although her T-cells collaborated with autologous 
      B-cells as well as B-cells from a brother with identical HLA-A, -B and -D. This 
      indicates that the mechanism which in normal cases overcomes HLA antigen 
      incompatibility was defective in this case. It further indicates that one of the 
      mechanisms necessary in B- and T-cell interaction requires HLA compatibility.
FAU - Yata, J
AU  - Yata J
FAU - Kobayashi, N
AU  - Kobayashi N
FAU - Shimbo, T
AU  - Shimbo T
FAU - Kakihara, U
AU  - Kakihara U
FAU - Sugahara, M
AU  - Sugahara M
FAU - Yamakura, T
AU  - Yamakura T
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - J Clin Lab Immunol
JT  - Journal of clinical & laboratory immunology
JID - 7808987
RN  - 0 (HLA Antigens)
RN  - 0 (Pokeweed Mitogens)
SB  - IM
MH  - Antibody-Producing Cells/cytology/*immunology
MH  - B-Lymphocytes/cytology/*immunology
MH  - Cell Differentiation
MH  - *HLA Antigens
MH  - *Histocompatibility
MH  - Humans
MH  - Immunologic Deficiency Syndromes/immunology
MH  - Pokeweed Mitogens/pharmacology
MH  - T-Lymphocytes/*immunology
EDAT- 1978/11/01 00:00
MHDA- 1978/11/01 00:01
CRDT- 1978/11/01 00:00
PHST- 1978/11/01 00:00 [pubmed]
PHST- 1978/11/01 00:01 [medline]
PHST- 1978/11/01 00:00 [entrez]
PST - ppublish
SO  - J Clin Lab Immunol. 1978 Nov;1(3):245-8.