PMID- 31547176
OWN - NLM
STAT- MEDLINE
DCOM- 20200204
LR  - 20200204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 19
DP  - 2019 Sep 20
TI  - Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury 
      in Noise Exposed Mice by Repressing Local Ceramide Accumulation.
LID - 10.3390/ijms20194675 [doi]
LID - 4675
AB  - Noise-induced hearing loss (NIHL) relates closely to auditory cortex (AC) injury, 
      so countermeasures aiming at the AC recovery would be of benefit. In this work, 
      the effect of hyperbaric oxygen treatment on NIHL was elucidated, which was 
      imposed on mice before (HBOP), during (HBOD) or after (HBOA) noise exposure. 
      Morphology of neurons was assayed by hematoxylin-eosin or Nissl staining. 
      Ceramide (Cer) level was measured through immunohistochemistry analysis. 
      Apoptotic neurons were counted using transferase-mediated dUTP nick end labeling 
      (TUNEL) staining. We demonstrated that the intense, broad band noise raised the 
      threshold of auditory brainstem response, evoked neuronal degeneration or 
      apoptosis and triggered the Cer accumulation in AC, all of which were restored 
      significantly by HBOP, but not HBOD or HBOA. Cer over-generation reversed the 
      advantages of HBOP significantly, while its curtailment recapitulated the effect. 
      Next, noise exposure raised the superoxide or malondialdehyde (MDA) production 
      which was blocked by HBOP or Cer repression. Oxidative control not only 
      attenuated the hearing loss or neurodegeneration but, in turn, reduced the Cer 
      formation significantly. In summary, mutual regulation between Cer and oxidative 
      stress underlies the HBOP's curative effect on hearing loss and neuronal damage 
      in noise-exposed mice.
FAU - Su, Yu-Ting
AU  - Su YT
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. sssusyt@163.com.
FAU - Guo, Yi-Bin
AU  - Guo YB
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. gyyb036@163.com.
FAU - Cheng, Yao-Ping
AU  - Cheng YP
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. cyp19890316@163.com.
FAU - Zhang, Xi
AU  - Zhang X
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. zhangxi2015@fmmu.edu.cn.
FAU - Xie, Xiao-Ping
AU  - Xie XP
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. xielaoshi133@126.com.
FAU - Chang, Yao-Ming
AU  - Chang YM
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. changzhuren@126.com.
FAU - Bao, Jun-Xiang
AU  - Bao JX
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an 
      710032, Shaanxi, China. baojunx@fmmu.edu.cn.
LA  - eng
GR  - 81671856/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20190920
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Ceramides)
SB  - IM
MH  - Animals
MH  - *Auditory Cortex/pathology/physiopathology
MH  - Ceramides/*metabolism
MH  - *Hearing Loss/metabolism/pathology/physiopathology/therapy
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Mice
MH  - Noise/*adverse effects
PMC - PMC6801451
OTO - NOTNLM
OT  - acid ceramidase
OT  - acid sphingomyelinase
OT  - ceramide
OT  - hearing loss
OT  - hyperbaric oxygen therapy
OT  - noise
OT  - oxidative stress
COIS- The authors declare no conflicts of interest.
EDAT- 2019/09/25 06:00
MHDA- 2020/02/06 06:00
PMCR- 2019/10/01
CRDT- 2019/09/25 06:00
PHST- 2019/07/16 00:00 [received]
PHST- 2019/09/08 00:00 [revised]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2019/09/25 06:00 [entrez]
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - ijms20194675 [pii]
AID - ijms-20-04675 [pii]
AID - 10.3390/ijms20194675 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Sep 20;20(19):4675. doi: 10.3390/ijms20194675.