PMID- 31547370
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 8
IP  - 9
DP  - 2019 Sep 12
TI  - Roles of mTOR Signaling in Tissue Regeneration.
LID - 10.3390/cells8091075 [doi]
LID - 1075
AB  - The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase 
      and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) 
      family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 
      and mTORC2. mTORC1 coordinates cell growth and metabolism in response to 
      environmental input, including growth factors, amino acid, energy and stress. 
      mTORC2 mainly controls cell survival and migration through phosphorylating 
      glucocorticoid-regulated kinase (SGK), protein kinase B (Akt), and protein kinase 
      C (PKC) kinase families. The dysregulation of mTOR is involved in human diseases 
      including cancer, cardiovascular diseases, neurodegenerative diseases, and 
      epilepsy. Tissue damage caused by trauma, diseases or aging disrupt the tissue 
      functions. Tissue regeneration after injuries is of significance for recovering 
      the tissue homeostasis and functions. Mammals have very limited regenerative 
      capacity in multiple tissues and organs, such as the heart and central nervous 
      system (CNS). Thereby, understanding the mechanisms underlying tissue 
      regeneration is crucial for tissue repair and regenerative medicine. mTOR is 
      activated in multiple tissue injuries. In this review, we summarize the roles of 
      mTOR signaling in tissue regeneration such as neurons, muscles, the liver and the 
      intestine.
FAU - Wei, Xiangyong
AU  - Wei X
AD  - Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest 
      University, Beibei, Chongqing 400715, China. xiangyongwei2016@outlook.com.
FAU - Luo, Lingfei
AU  - Luo L
AD  - Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest 
      University, Beibei, Chongqing 400715, China. lluo@swu.edu.cn.
FAU - Chen, Jinzi
AU  - Chen J
AD  - Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest 
      University, Beibei, Chongqing 400715, China. chjz2012@email.swu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190912
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Mechanistic Target of Rapamycin Complex 1/chemistry/metabolism
MH  - *Mechanistic Target of Rapamycin Complex 2/chemistry/metabolism
MH  - Regeneration/*physiology
MH  - Signal Transduction/*physiology
PMC - PMC6769890
OTO - NOTNLM
OT  - intestine
OT  - liver
OT  - mTOR signaling
OT  - metabolism
OT  - muscle
OT  - neuron
OT  - tissue regeneration
COIS- The authors declare no conflict of interest.
EDAT- 2019/09/25 06:00
MHDA- 2020/05/12 06:00
PMCR- 2019/09/01
CRDT- 2019/09/25 06:00
PHST- 2019/08/09 00:00 [received]
PHST- 2019/09/06 00:00 [revised]
PHST- 2019/09/07 00:00 [accepted]
PHST- 2019/09/25 06:00 [entrez]
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - cells8091075 [pii]
AID - cells-08-01075 [pii]
AID - 10.3390/cells8091075 [doi]
PST - epublish
SO  - Cells. 2019 Sep 12;8(9):1075. doi: 10.3390/cells8091075.