PMID- 31548563
OWN - NLM
STAT- MEDLINE
DCOM- 20201030
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Sep 23
TI  - Glucagon-like peptide-2 rescues memory impairments and neuropathological changes 
      in a mouse model of dementia induced by the intracerebroventricular 
      administration of streptozotocin.
PG  - 13723
LID - 10.1038/s41598-019-50167-3 [doi]
LID - 13723
AB  - Glucagon-like peptide 2 (GLP-2) is derived from the proglucagon gene expressed in 
      the intestines, pancreas and brain. Our previous study showed that GLP-2 improved 
      lipopolysaccharide-induced memory impairments. The current study was designed to 
      further investigated the potential of GLP-2 in memory impairment induced by 
      intracerebroventricular administration of streptozotocin (ICV-STZ) in mice, which 
      have been used as an animal model of sporadic Alzheimer's disease (AD). STZ was 
      administered on alternate days (Day-1 and Day-3) in order to induce dementia in 
      male ddY mice. ICV-STZ-treated mice were administered GLP-2 (0.6 mug/mouse, ICV) 
      for 5 days from 14 days after the first ICV administration of STZ. In these mice, 
      we examined spatial working memory, the biochemical parameters of oxidative 
      stress, or neurogenesis. The GLP-2 treatment restored spatial working memory in 
      ICV-STZ-treated mice. ICV-STZ-treated mice showed markedly increased 
      thiobarbituric acid reactive species (TBARS) and decreased glutathione (GSH) 
      levels, and GLP-2 significantly restored these ICV-STZ-induced changes. GLP-2 
      also significantly restored neurogenesis in the subgranular zone of the dentate 
      gyrus in ICV-STZ-treated mice. We herein demonstrated that GLP-2 significantly 
      restored ICV-STZ-induced memory impairments as well as biochemical and 
      histopathological alterations, and accordingly, propose that the memory 
      restorative ability of GLP-2 is due to its potential to reduce oxidative stress.
FAU - Sasaki-Hamada, Sachie
AU  - Sasaki-Hamada S
AD  - Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University 
      of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
AD  - Department of Physiology, School of Allied Health Sciences, Kitasato University, 
      Sagamihara, 252-0373, Japan.
FAU - Ikeda, Masaatsu
AU  - Ikeda M
AD  - Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University 
      of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
FAU - Oka, Jun-Ichiro
AU  - Oka JI
AD  - Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University 
      of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. okaji@rs.noda.tus.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190923
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Glucagon-Like Peptide 2)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/metabolism/pathology
MH  - Dementia/chemically induced/*drug therapy/metabolism/pathology
MH  - Disease Models, Animal
MH  - Glucagon-Like Peptide 2/pharmacology/*therapeutic use
MH  - Male
MH  - Memory Disorders/chemically induced/*drug therapy/metabolism/pathology
MH  - Mice
MH  - Neurogenesis/drug effects
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Spatial Memory/*drug effects
MH  - Streptozocin
MH  - Thiobarbituric Acid Reactive Substances/metabolism
PMC - PMC6757030
COIS- The authors declare no competing interests.
EDAT- 2019/09/25 06:00
MHDA- 2020/10/31 06:00
PMCR- 2019/09/23
CRDT- 2019/09/25 06:00
PHST- 2019/01/30 00:00 [received]
PHST- 2019/09/06 00:00 [accepted]
PHST- 2019/09/25 06:00 [entrez]
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2020/10/31 06:00 [medline]
PHST- 2019/09/23 00:00 [pmc-release]
AID - 10.1038/s41598-019-50167-3 [pii]
AID - 50167 [pii]
AID - 10.1038/s41598-019-50167-3 [doi]
PST - epublish
SO  - Sci Rep. 2019 Sep 23;9(1):13723. doi: 10.1038/s41598-019-50167-3.