PMID- 31548841
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1710-1484 (Print)
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Linking)
VI  - 15
DP  - 2019
TI  - Serum IL-1beta can be a biomarker in children with severe persistent allergic 
      rhinitis.
PG  - 58
LID - 10.1186/s13223-019-0368-8 [doi]
LID - 58
AB  - BACKGROUND: Allergic rhinitis (AR) is one of the most common diseases globally 
      and usually persists throughout life. In the present study, we aimed to determine 
      whether the expression of inflammatory biomarkers has a relationship with the 
      severity of allergic rhinitis and with comorbid asthma or other allergic diseases 
      in children. METHODS: For diagnosis of AR, the skin prick test was performed to 
      measure the responses to 18 allergens. Blood levels of eosinophils and 
      immunoglobulin E (IgE) were examined. We classified the patients into 2 groups 
      based on the severity of the condition as Group 1 [intermittent AR (IAR) or mild 
      persistent AR (PAR)] and Group 2 (moderate to severe PAR). To determine the 
      expression of inflammatory biomarkers, in serum and several biomarkers 
      (caspase-1, IL-1beta, CCL-11, CCL-24 and IL-33) were measured in the serum using 
      enzyme-linked immunosorbent assay (ELISA). Additionally, we analyzed the 
      correlation between clinical variables and the expression of biomarkers 
      (eosinophils count, IL-1beta and CCL-24) and the severity of AR. RESULTS: We found 
      that eosinophils count, IL-1beta, a marker of activation of inflammasomes, and 
      CCL-24 were significantly increased in the moderate to severe PAR group 
      (p = 0.008, p = 0.003, p = 0.039). Additionally, the expressions of eosinophil 
      count, IL-1beta and CCL-24 were significantly higher in patients with active 
      asthmatic symptoms than in those without these conditions. On univariate 
      analysis, allergic rhinitis in sibling, paternal allergic rhinitis, high 
      expression of eosinophils count, IL-1beta and CCL-24, history of active asthma and 
      atopy correlated with severity of AR. Multivariate analysis showed only paternal 
      allergic rhinitis and high expression of IL-1beta as significant risk factors of 
      moderate to severe PAR with 6.4 fold and 4.7 fold-increase in risk, respectively 
      (p = 0.011 and p = 0.030). CONCLUSION: In conclusion, this study provides the 
      first evidence that an excessive release of biologically active IL-1beta may promote 
      inflammation in severe PAR. It demonstrates that IL-1beta can be a biomarker for 
      active allergic diseases such as AR, asthma, and atopy. Moreover, this finding 
      suggests that IL-1B should be investigated as a therapeutic target in severe PAR 
      and other allergic diseases.
FAU - Han, Myung Woul
AU  - Han MW
AUID- ORCID: 0000-0001-8596-7699
AD  - 1Department of Otolaryngology, Ulsan University Hospital, University of Ulsan 
      College of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 44033 Republic of 
      Korea. ISNI: 0000 0004 0533 4667. GRID: grid.267370.7
FAU - Kim, Song Hee
AU  - Kim SH
AD  - 1Department of Otolaryngology, Ulsan University Hospital, University of Ulsan 
      College of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 44033 Republic of 
      Korea. ISNI: 0000 0004 0533 4667. GRID: grid.267370.7
FAU - Oh, Inbo
AU  - Oh I
AD  - 2Environmental Health Center, University of Ulsan College of Medicine, Ulsan, 
      Republic of Korea. ISNI: 0000 0004 0533 4667. GRID: grid.267370.7
FAU - Kim, Yang Ho
AU  - Kim YH
AD  - 3Department of Occupational and Environmental Medicine, Ulsan University 
      Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwan-doro, 
      Dong-gu, Ulsan, 44033 Republic of Korea. ISNI: 0000 0004 0533 4667. GRID: 
      grid.267370.7
FAU - Lee, Jiho
AU  - Lee J
AD  - 3Department of Occupational and Environmental Medicine, Ulsan University 
      Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwan-doro, 
      Dong-gu, Ulsan, 44033 Republic of Korea. ISNI: 0000 0004 0533 4667. GRID: 
      grid.267370.7
LA  - eng
PT  - Journal Article
DEP - 20190918
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC6749717
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Asthma
OT  - Atopy
OT  - Biomarker
OT  - IL-1beta
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2019/09/25 06:00
MHDA- 2019/09/25 06:01
PMCR- 2019/09/18
CRDT- 2019/09/25 06:00
PHST- 2019/01/08 00:00 [received]
PHST- 2019/08/27 00:00 [accepted]
PHST- 2019/09/25 06:00 [entrez]
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2019/09/25 06:01 [medline]
PHST- 2019/09/18 00:00 [pmc-release]
AID - 368 [pii]
AID - 10.1186/s13223-019-0368-8 [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2019 Sep 18;15:58. doi: 10.1186/s13223-019-0368-8. 
      eCollection 2019.