PMID- 31550409
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jan
TI  - Non-HLA donor-recipient mismatches in kidney transplantation-A stone left 
      unturned.
PG  - 19-24
LID - 10.1111/ajt.15612 [doi]
AB  - In kidney transplantation, short-term allograft survival has improved due to 
      improvements in acute rejection episodes without corresponding improvements in 
      long-term survival. Although current organ allocation algorithms take into 
      account human leukocyte antigen (HLA) matching to reduce antidonor alloimmune 
      responses, it is likely that genomic variation at non-HLA loci (ie, non-HLA 
      donor-recipient [D-R] pair mismatches) play a role in the "non-self" responses 
      and ultimately affect long-term allograft survival. Existing data from both 
      animal models and human studies suggest an association between non-HLA D-R 
      mismatches and kidney allograft outcomes. In this minireview, we examine existing 
      and emerging data and discuss putative mechanisms on the role of non-HLA D-R 
      mismatches on long-term allograft outcomes in kidney transplantation.
CI  - (c) 2019 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Farouk, Samira
AU  - Farouk S
AUID- ORCID: 0000-0001-5598-5925
AD  - Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount 
      Sinai, New York, NY.
AD  - Recanati-Miller transplant Institute, Icahn School of Medicine at Mount Sinai, 
      New York, NY.
FAU - Zhang, Zhongyang
AU  - Zhang Z
AD  - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount 
      Sinai, New York, NY.
AD  - Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine 
      at Mount Sinai, New York, NY.
FAU - Menon, Madhav C
AU  - Menon MC
AUID- ORCID: 0000-0002-9567-4299
AD  - Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount 
      Sinai, New York, NY.
AD  - Recanati-Miller transplant Institute, Icahn School of Medicine at Mount Sinai, 
      New York, NY.
LA  - eng
GR  - R01 DK122164/DK/NIDDK NIH HHS/United States
GR  - U01 AI063594/AI/NIAID NIH HHS/United States
GR  - U01 AI070107/AI/NIAID NIH HHS/United States
GR  - Clinical Trials in Organ Transplantation-19/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191019
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Graft Rejection/*etiology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Tissue Donors
MH  - Transplant Recipients
PMC - PMC7898079
MID - NIHMS1051716
OTO - NOTNLM
OT  - editorial
OT  - genetics
OT  - genomics
OT  - kidney transplantation
OT  - nephrology
OT  - personal viewpoint
OT  - science
OT  - translational research
COIS- Disclosure The authors of this manuscript have no conflicts to disclose as 
      described by the American Journal of Transplantation.
EDAT- 2019/09/25 06:00
MHDA- 2021/01/12 06:00
PMCR- 2021/02/22
CRDT- 2019/09/25 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2019/08/28 00:00 [revised]
PHST- 2019/09/17 00:00 [accepted]
PHST- 2019/09/25 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2019/09/25 06:00 [entrez]
PHST- 2021/02/22 00:00 [pmc-release]
AID - S1600-6135(22)10038-9 [pii]
AID - 10.1111/ajt.15612 [doi]
PST - ppublish
SO  - Am J Transplant. 2020 Jan;20(1):19-24. doi: 10.1111/ajt.15612. Epub 2019 Oct 19.