PMID- 31554253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 11
IP  - 10
DP  - 2019 Sep 24
TI  - The Emerging Roles of mTORC1 in Macromanaging Autophagy.
LID - 10.3390/cancers11101422 [doi]
LID - 1422
AB  - Autophagy is a process of self-degradation that enables the cell to survive when 
      faced with starvation or stressful conditions. The mechanistic target of 
      rapamycin (mTOR), also known as the mammalian target of rapamycin, plays a 
      critical role in maintaining a balance between cellular anabolism and catabolism. 
      mTOR complex 1 (mTORC1) was unveiled as a master regulator of autophagy since 
      inhibition of mTORC1 was required to initiate the autophagy process. Evidence has 
      emerged in recent years to indicate that mTORC1 also directly regulates the 
      subsequent steps of the autophagy process, including the nucleation, 
      autophagosome elongation, autophagosome maturation and termination. By 
      phosphorylating select protein targets of the autophagy core machinery and/or 
      their regulators, mTORC1 can alter their functions, increase their proteasomal 
      degradation or modulate their acetylation status, which is a key switch of the 
      autophagy process. Moreover, it phosphorylates and alters the subcellular 
      localization of transcription factors to suppress the expression of genes needed 
      for autophagosome formation and lysosome biogenesis. The purpose of this review 
      article is to critically analyze current literatures to provide an integrated 
      view of how mTORC1 regulates various steps of the autophagy process.
FAU - Dossou, Akpedje S
AU  - Dossou AS
AUID- ORCID: 0000-0002-9844-8860
AD  - Department of Microbiology, Immunology and Genetics, University of North Texas 
      Health Science Center, Fort Worth, TX 76107, USA. Akpedje.Dossou@my.unthsc.edu.
FAU - Basu, Alakananda
AU  - Basu A
AUID- ORCID: 0000-0002-1656-0788
AD  - Department of Microbiology, Immunology and Genetics, University of North Texas 
      Health Science Center, Fort Worth, TX 76107, USA. Alakananda.basu@unthsc.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190924
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC6826502
OTO - NOTNLM
OT  - AMPK
OT  - ULK1
OT  - autophagosome maturation
OT  - autophagy initiation
OT  - autophagy regulation
OT  - elongation
OT  - mTORC1 substrates
OT  - macroautophagy
OT  - nucleation
OT  - transcriptional regulation
COIS- The authors declares no conflict of interest.
EDAT- 2019/09/27 06:00
MHDA- 2019/09/27 06:01
PMCR- 2019/09/24
CRDT- 2019/09/27 06:00
PHST- 2019/08/25 00:00 [received]
PHST- 2019/09/22 00:00 [revised]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/09/27 06:00 [entrez]
PHST- 2019/09/27 06:00 [pubmed]
PHST- 2019/09/27 06:01 [medline]
PHST- 2019/09/24 00:00 [pmc-release]
AID - cancers11101422 [pii]
AID - cancers-11-01422 [pii]
AID - 10.3390/cancers11101422 [doi]
PST - epublish
SO  - Cancers (Basel). 2019 Sep 24;11(10):1422. doi: 10.3390/cancers11101422.