PMID- 31555149
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 10
DP  - 2019
TI  - Vitamin D Receptor Deficiency Does Not Affect Blood Pressure and Heart Function.
PG  - 1118
LID - 10.3389/fphys.2019.01118 [doi]
LID - 1118
AB  - Vitamin D is thought to play a role in blood pressure regulation, which in turn 
      can influence cardiovascular risk. Several meta-analyses of cohort studies found 
      low serum levels of 25-hydroxyvitamin D to be associated with increased blood 
      pressure or increased cardiovascular morbidity and mortality in the general 
      population. Active vitamin D mediates its function via the vitamin D receptor 
      (Vdr), which is a ligand-activated transcription factor. A suitable model to 
      examine the causal role of vitamin D in blood pressure regulation and heart 
      function is the Vdr knockout (Vdr(-/-)) mouse. To elucidate the role of vitamin D 
      on blood pressure, heart function, and cardiac myocyte size, we conducted a 
      long-term study using Vdr(-/-) mice and well-defined diets. Group 1 comprised 
      Vdr(-/-) mice that received a high-calcium, high-phosphorus rescue diet to 
      prevent hypocalcemia and a rickets phenotype. Groups 2 and 3 included Vdr(+/+) 
      mice that were fed either the rescue diet or a control diet containing normal 
      amounts of these minerals. As Vdr is a nuclear factor that regulates 
      transcription, we analyzed the renal mRNA expression and serum concentration of 
      renin and found that the Vdr(-/-) group had an almost 50% higher renin mRNA 
      expression in the kidney compared to both groups of Vdr(+/+) mice. Additionally, 
      serum concentration of renin in Vdr(-/-) mice was significantly higher than that 
      of Vdr(+/+) mice that received the rescue or control diet (+ 17%,+ 32%; P < 
      0.05). In contrast, renin activity was lower in Vdr(-/-) mice than in both groups 
      of Vdr(+/+) mice (P < 0.05). However, blood pressure, heart rate, cardiac myocyte 
      sizes, and the expression of renal renin receptor, hepatic angiotensinogen and 
      angiotensin II receptor, type 1, in kidney, liver and heart, did not differ 
      between the three groups of mice. Additionally, data from transthoracic 
      echocardiography did not indicate the role of Vdr on heart function, as the left 
      ventricular ejection fraction, fractional shortening, and velocity of blood flow 
      were comparable between the three groups. To conclude, the roles of Vdr and 
      therefore most probably of vitamin D, in blood pressure regulation and heart 
      function, were not confirmed by our findings.
FAU - Grundmann, Sarah M
AU  - Grundmann SM
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), 
      Halle-Jena-Leipzig, Leipzig, Germany.
FAU - Schutkowski, Alexandra
AU  - Schutkowski A
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
FAU - Schreier, Barbara
AU  - Schreier B
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), 
      Halle-Jena-Leipzig, Leipzig, Germany.
AD  - Julius Bernstein Institute of Physiology, Faculty of Medicine, Martin Luther 
      University Halle-Wittenberg, Halle (Saale), Germany.
FAU - Rabe, Sindy
AU  - Rabe S
AD  - Julius Bernstein Institute of Physiology, Faculty of Medicine, Martin Luther 
      University Halle-Wittenberg, Halle (Saale), Germany.
FAU - Konig, Bettina
AU  - Konig B
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), 
      Halle-Jena-Leipzig, Leipzig, Germany.
FAU - Gekle, Michael
AU  - Gekle M
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), 
      Halle-Jena-Leipzig, Leipzig, Germany.
AD  - Julius Bernstein Institute of Physiology, Faculty of Medicine, Martin Luther 
      University Halle-Wittenberg, Halle (Saale), Germany.
FAU - Stangl, Gabriele I
AU  - Stangl GI
AD  - Institute of Agricultural and Nutritional Sciences, Martin Luther University 
      Halle-Wittenberg, Halle (Saale), Germany.
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), 
      Halle-Jena-Leipzig, Leipzig, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190829
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6727788
OTO - NOTNLM
OT  - blood pressure
OT  - heart function
OT  - mice
OT  - vitamin D
OT  - vitamin D receptor
EDAT- 2019/09/27 06:00
MHDA- 2019/09/27 06:01
PMCR- 2019/08/29
CRDT- 2019/09/27 06:00
PHST- 2019/03/27 00:00 [received]
PHST- 2019/08/13 00:00 [accepted]
PHST- 2019/09/27 06:00 [entrez]
PHST- 2019/09/27 06:00 [pubmed]
PHST- 2019/09/27 06:01 [medline]
PHST- 2019/08/29 00:00 [pmc-release]
AID - 10.3389/fphys.2019.01118 [doi]
PST - epublish
SO  - Front Physiol. 2019 Aug 29;10:1118. doi: 10.3389/fphys.2019.01118. eCollection 
      2019.