PMID- 31555382
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 18
IP  - 4
DP  - 2019 Oct
TI  - Prognostic value of fibrinogen-to-albumin ratio in predicting 1-year clinical 
      progression in patients with non-ST elevation acute coronary syndrome undergoing 
      percutaneous coronary intervention.
PG  - 2972-2978
LID - 10.3892/etm.2019.7890 [doi]
AB  - Previous studies have indicated that fibrinogen and low serum albumin levels are 
      associated with poor cardiovascular outcomes. The objective of the present study 
      was to examine whether the fibrinogen-to-albumin ratio (FAR) was able to predict 
      the 1-year prognosis of patients with non-ST elevation acute coronary syndrome 
      (NSTE-ACS) following percutaneous coronary intervention (PCI). A total of 1,352 
      patients with NSTE-ACS undergoing PCI were included in this prospective study and 
      were divided into a low-FAR group (FAR </=8.713, n=901) and a high-FAR group 
      (FAR>8.713, n=451). FAR was defined as the concentration ratio of fibrinogen 
      (mg/dl) to albumin (mg/dl) multiplied by 100. The endpoint was the incidence of 
      major adverse cardiovascular events (MACEs), including all-cause mortality, 
      cardiac mortality, non-fatal myocardial reinfarction and unscheduled repeat 
      revascularisation. The predictive performance was validated by receiver-operator 
      characteristic (ROC) curve analysis. A total of 127 MACEs were noted during the 
      1-year follow-up period. Multivariate Cox analysis suggested that a high FAR was 
      an independent predictor of all-cause mortality (hazard ratio=2.223, 95% 
      confidence interval: 1.002-4.931, P=0.049). Regarding the predictor of MACEs, the 
      FAR exhibited an area under the ROC curve of 0.676 with a sensitivity of 0.630 
      and a specificity of 0.726. The cut-off value was 9.114. The FAR was an 
      independent prognostic factor in NSTE-ACS. The present results suggest that the 
      FAR may serve as a potential prognostic indicator for patients with NSTE-ACS 
      undergoing PCI (approval no. NCT02667548; January 29, 2016; Shengjing Hospital of 
      China Medical University).
FAU - He, Dongxu
AU  - He D
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Jiao, Yundi
AU  - Jiao Y
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Yu, Tongtong
AU  - Yu T
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Song, Jia
AU  - Song J
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Wen, Zongyu
AU  - Wen Z
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Wu, Jiake
AU  - Wu J
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Duan, Weili
AU  - Duan W
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Sun, Na
AU  - Sun N
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Sun, Zhijun
AU  - Sun Z
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
FAU - Sun, Zhaoqing
AU  - Sun Z
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning 110022, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190814
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6755427
OTO - NOTNLM
OT  - fibrinogen-to-albumin ratio
OT  - major adverse cardiovascular events
OT  - non-ST elevation acute coronary syndrome
OT  - percutaneous coronary intervention
EDAT- 2019/09/27 06:00
MHDA- 2019/09/27 06:01
PMCR- 2019/08/14
CRDT- 2019/09/27 06:00
PHST- 2018/10/19 00:00 [received]
PHST- 2019/06/06 00:00 [accepted]
PHST- 2019/09/27 06:00 [entrez]
PHST- 2019/09/27 06:00 [pubmed]
PHST- 2019/09/27 06:01 [medline]
PHST- 2019/08/14 00:00 [pmc-release]
AID - ETM-0-0-7890 [pii]
AID - 10.3892/etm.2019.7890 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Oct;18(4):2972-2978. doi: 10.3892/etm.2019.7890. Epub 2019 Aug 
      14.