PMID- 31556342
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 14
IP  - 10
DP  - 2019 Oct
TI  - Repair of lumbar vertebral bone defects by bone particles combined with hUC-MSCs 
      in weaned rabbit.
PG  - 915-923
LID - 10.2217/rme-2018-0134 [doi]
AB  - Aim: The major symptom of many closed spinal dysraphism patients is that the 
      laminas or arches of vertebra are not fused well. To date, the bone repair of 
      spina bifida for young children is a significant challenge in clinical practice. 
      Materials & methods: Bovine bone collagen particle (BBCP) scaffolds combined with 
      human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were implanted in 
      the defect area. X-ray analysis was performed after 3 months. Tissues were 
      harvested for gross observation, and histological and immunohistochemical 
      staining. Results: The BBCP supported hUC-MSCs adhesion and growth. Implanted 
      BBCP combined with hUC-MSCs also promoted bone regeneration in the vertebral 
      lamina and arch defect area. Conclusion: This method represents a new strategy 
      for vertebral lamina and arch reconstruction in children.
FAU - Cui, Yi
AU  - Cui Y
AD  - Reproductive & Genetic Center, National Research Institute for Family Planning, 
      Beijing 100081, PR China.
FAU - Xu, Bai
AU  - Xu B
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Yin, Yanyun
AU  - Yin Y
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Chen, Bing
AU  - Chen B
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Zhao, Yannan
AU  - Zhao Y
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Xiao, Zhifeng
AU  - Xiao Z
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Yang, Bin
AU  - Yang B
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Meng, Qingyuan
AU  - Meng Q
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
FAU - Fang, Yongxiang
AU  - Fang Y
AD  - State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of 
      Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research 
      Institute, CAAS, Lanzhou 730046, PR China.
FAU - Liang, Qinghan
AU  - Liang Q
AD  - Department of Gynaecology, Beijing haidian maternal & child health hospital, 
      Beijing 100089, PR China.
FAU - Zhou, Ling
AU  - Zhou L
AD  - Department of Gynaecology & Obstetrics, Strategic Support Force Medical Centre of 
      PLA, Beijing 100101, PR China.
FAU - Ma, Xu
AU  - Ma X
AD  - Reproductive & Genetic Center, National Research Institute for Family Planning, 
      Beijing 100081, PR China.
FAU - Dai, Jianwu
AU  - Dai J
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics & 
      Developmental Biology, Chinese Academy of Sciences, Beijing 100080, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190926
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - *Bone Regeneration
MH  - Cattle
MH  - *Cells, Immobilized/metabolism/pathology/transplantation
MH  - Collagen/*chemistry
MH  - Humans
MH  - *Lumbar Vertebrae/injuries/metabolism/pathology
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells/metabolism/pathology
MH  - Rabbits
MH  - *Umbilical Cord/metabolism/pathology
OTO - NOTNLM
OT  - BBCP
OT  - bone regeneration
OT  - hUC-MSCs
OT  - lamina vertebral defects
OT  - weaned rabbit
EDAT- 2019/09/27 06:00
MHDA- 2020/04/03 06:00
CRDT- 2019/09/27 06:00
PHST- 2019/09/27 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2019/09/27 06:00 [entrez]
AID - 10.2217/rme-2018-0134 [doi]
PST - ppublish
SO  - Regen Med. 2019 Oct;14(10):915-923. doi: 10.2217/rme-2018-0134. Epub 2019 Sep 26.