PMID- 31557724
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 8
IP  - 10
DP  - 2019 Oct
TI  - MEN1-associated primary hyperparathyroidism in the Spanish Registry: clinical 
      characterictics and surgical outcomes.
PG  - 1416-1424
LID - 10.1530/EC-19-0321 [doi]
AB  - Primary hyperparathyroidism is the most frequent manifestation of multiple 
      endocrine neoplasia type 1 (MEN1) syndrome. Bone and renal complications are 
      common. Surgery is the treatment of choice, but the best timing for surgery is 
      controversial and predictors of persistence and recurrence are not well known. 
      Our study describes the clinical characteristics and the surgical outcomes, after 
      surgery and in the long term, of the patients with MEN1 and primary 
      hyperparathyroidism included in the Spanish Registry of Multiple Endocrine 
      Neoplasia, Pheochromocytomas and Paragangliomas (REGMEN). Eighty-nine patients 
      (49 men and 40 women, 34.2 +/- 13 years old) were included. Sixty-four out of the 
      89 underwent surgery: a total parathyroidectomy was done in 13 patients, a 
      subtotal parathyroidectomy in 34 and a less than subtotal parathyroidectomy in 
      15. Remission rates were higher after a total or a subtotal parathyroidectomy 
      than after a less than subtotal (3/4 and 20/22 vs 7/12, P < 0.05), without 
      significant differences in permanent hypoparathyroidism (1/5, 9/23 and 0/11, 
      N.S.). After a median follow-up of 111 months, 20 of the 41 operated patients 
      with long-term follow-up had persistent or recurrent hyperparathyroidism. We did 
      not find differences in disease-free survival rates between different techniques, 
      patients with or without permanent hypoparathyroidism and patients with different 
      mutated exons, but a second surgery was more frequent after a less than subtotal 
      parathyroidectomy.
FAU - Lamas, Cristina
AU  - Lamas C
AD  - Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de 
      Albacete, Albacete, Spain.
FAU - Navarro, Elena
AU  - Navarro E
AD  - Department of Endocrinology and Nutrition, Hospital Universitario Virgen del 
      Rocio, Sevilla, Spain.
FAU - Casteras, Anna
AU  - Casteras A
AD  - Department of Endocrinology and Nutrition, Hospital Vall d'Hebron, Barcelona, 
      Spain.
FAU - Portillo, Paloma
AU  - Portillo P
AD  - Department of Endocrinology and Nutrition, Hospital Clinico Universitario Virgen 
      de la Arrixaca, Murcia, Spain.
FAU - Alcazar, Victoria
AU  - Alcazar V
AD  - Department of Endocrinology and Nutrition, Hospital Universitario Severo Ochoa, 
      Leganes, Spain.
FAU - Calatayud, Maria
AU  - Calatayud M
AD  - Department of Endocrinology and Nutrition, Hospital Univeristario Doce de 
      Octubre, Madrid, Spain.
FAU - Alvarez-Escola, Cristina
AU  - Alvarez-Escola C
AD  - Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, 
      Spain.
FAU - Sastre, Julia
AU  - Sastre J
AD  - Department of Endocrinology and Nutrition, Complejo Hospitalario de Toledo, 
      Hospital Virgen de la Salud, Toledo, Spain.
FAU - Boix, Evangelina
AU  - Boix E
AD  - Department of Endocrinology and Nutrition, Hospital General Universitario de 
      Elche, Elche, Spain.
FAU - Forga, Lluis
AU  - Forga L
AD  - Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, 
      Hospital de Navarra, Pamplona, Spain.
FAU - Vicente, Almudena
AU  - Vicente A
AD  - Department of Endocrinology and Nutrition, Complejo Hospitalario de Toledo, 
      Hospital Virgen de la Salud, Toledo, Spain.
FAU - Oriola, Josep
AU  - Oriola J
AD  - Biochemistry and Molecular Genetics Department, Hospital Clinic i Universitari de 
      Barcelona, Barcelona, Spain.
FAU - Mesa, Jordi
AU  - Mesa J
AD  - Department of Endocrinology and Nutrition, Hospital Vall d'Hebron, Barcelona, 
      Spain.
FAU - Valdes, Nuria
AU  - Valdes N
AD  - Department of Endocrinology and Nutrition, Hospital Universitario Central de 
      Asturias, Oviedo, Spain.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC6826168
OTO - NOTNLM
OT  - MEN1 gene
OT  - hypoparathyroidism
OT  - multiple endocrine neoplasia type 1
OT  - parathyroidectomy
OT  - primary hyperparathyroidism
EDAT- 2019/09/27 06:00
MHDA- 2019/09/27 06:01
PMCR- 2019/09/23
CRDT- 2019/09/27 06:00
PHST- 2019/09/15 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/09/27 06:00 [pubmed]
PHST- 2019/09/27 06:01 [medline]
PHST- 2019/09/27 06:00 [entrez]
PHST- 2019/09/23 00:00 [pmc-release]
AID - EC-19-0321.R2 [pii]
AID - EC-19-0321 [pii]
AID - 10.1530/EC-19-0321 [doi]
PST - ppublish
SO  - Endocr Connect. 2019 Oct;8(10):1416-1424. doi: 10.1530/EC-19-0321.