PMID- 31558152
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200225
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Sep 26
TI  - The diffuse involvement of anti-N-methyl-D-aspartate receptor encephalitis in 
      brain: a case report.
PG  - 230
LID - 10.1186/s12883-019-1456-6 [doi]
LID - 230
AB  - BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe 
      and most common autoimmune encephalitis in patients under 40 years old. 
      Anti-NMDAR encephalitis has various clinical and neuroimaging findings. Here we 
      report a special case of an anti-NMDAR encephalitis who had diffuse lesions in 
      bilateral hemispheres with mild mass effects in left basal ganglia area. CASE 
      PRESENTATIONS: A 28-year-old female anti-NMDAR encephalitis patient mainly 
      presented with headache and fever. Brain magnetic resonance image (MRI) showed 
      slightly contrasted diffuse lesions, involving the left temporal and frontal 
      lobes, left basal ganglia area and splenium of corpus callosum, as well as the 
      right frontal lobe, with mild edema surrounded in the left basal ganglia area. 
      Cerebrospinal fluid (CSF) revealed a moderate pleocytosis with normal protein and 
      glucose levels. Anti-NMDAR antibodies were identified in CSF. Transvaginal 
      ovarian ultrasound did not reveal an ovarian teratoma. The patient was treated 
      with immunoglobulin and steroid, and had a good recovery. CONCLUSIONS: Anti-NMDAR 
      encephalitis has no special clinical manifestations and brain MRI is highly 
      variable, which could be unremarkable or abnormal involving white and grey 
      matters. The extensive lesions in frontal and temporal lobes, and basal ganglia 
      area, with mild mass effects, have not been described previously. Recognition of 
      various changes in brain MRI will enable the early detection of anti-NMDAR 
      antibody and then effective treatments.
FAU - Jiang, Yun
AU  - Jiang Y
AUID- ORCID: 0000-0003-4317-1515
AD  - Department of Neurology, Beijing Hospital, National Center of Gerontology, 
      Beijing, China. jiangyun@bjhmoh.cn.
FAU - Ma, Jianpeng
AU  - Ma J
AD  - Department of Neurology, Beijing Hospital, National Center of Gerontology, 
      Beijing, China.
AD  - Department of Neurology, Beijing Friendship Hospital, Beijing, China.
FAU - Gong, Tao
AU  - Gong T
AD  - Department of Neurology, Beijing Hospital, National Center of Gerontology, 
      Beijing, China.
FAU - Hao, Hongjun
AU  - Hao H
AD  - Department of Neurology, Peking University First Hospital, Beijing, China.
FAU - Chen, Haibo
AU  - Chen H
AD  - Department of Neurology, Beijing Hospital, National Center of Gerontology, 
      Beijing, China.
LA  - eng
GR  - BJ-2011-058/National Natural Science Foundation of China/
PT  - Case Reports
PT  - Journal Article
DEP - 20190926
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*diagnosis/*pathology
MH  - Basal Ganglia/diagnostic imaging/*pathology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/*pathology
MH  - Humans
MH  - Temporal Lobe/diagnostic imaging/*pathology
PMC - PMC6764129
OTO - NOTNLM
OT  - Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis
OT  - Brain
OT  - Clinic
OT  - Magnetic resonance image
COIS- The authors declared that they have no competing interests.
EDAT- 2019/09/29 06:00
MHDA- 2020/01/07 06:00
PMCR- 2019/09/26
CRDT- 2019/09/28 06:00
PHST- 2019/02/10 00:00 [received]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/09/28 06:00 [entrez]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/09/26 00:00 [pmc-release]
AID - 10.1186/s12883-019-1456-6 [pii]
AID - 1456 [pii]
AID - 10.1186/s12883-019-1456-6 [doi]
PST - epublish
SO  - BMC Neurol. 2019 Sep 26;19(1):230. doi: 10.1186/s12883-019-1456-6.