PMID- 31560644
OWN - NLM
STAT- MEDLINE
DCOM- 20200702
LR  - 20200702
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 16
DP  - 2019 Sep 26
TI  - Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and 
      Chronic Diseases: An Umbrella Review.
PG  - E132
LID - 10.5888/pcd16.180641 [doi]
LID - E132
AB  - INTRODUCTION: Studies have investigated the relationships between chronic 
      systemic and dental conditions, but it remains unclear how such knowledge can be 
      used in clinical practice. In this article, we provide an overview of existing 
      systematic reviews, identifying and evaluating the most frequently reported 
      dental-chronic disease correlations and common risk factors. METHODS: We 
      conducted a systematic review of existing systematic reviews (umbrella review) 
      published between 1995 and 2017 and indexed in 4 databases. We focused on the 3 
      most prevalent dental conditions and 10 chronic systemic diseases with the 
      highest burden of disease in Germany. Two independent reviewers assessed all 
      articles for eligibility and methodologic quality using the AMSTAR criteria and 
      extracted data from the included studies. RESULTS: Of the initially identified 
      1,249 systematic reviews, 32 were included for qualitative synthesis. The dental 
      condition with most frequently observed correlations to chronic systemic diseases 
      was periodontitis. The chronic systemic disease with the most frequently observed 
      correlations with a dental condition was type 2 diabetes mellitus (T2DM). Most 
      dental-chronic disease correlations were found between periodontitis and T2DM and 
      periodontitis and cardiovascular disease. Frequently reported common risk factors 
      were smoking, age, sex, and overweight. Using the AMSTAR criteria, 2 studies were 
      assessed as low quality, 26 studies as moderate quality, and 4 studies as high 
      quality. CONCLUSION: The quality of included systematic reviews was 
      heterogeneous. The most frequently reported correlations were found for 
      periodontitis with T2DM and for periodontitis with cardiovascular disease. 
      However, the strength of evidence for these and other disease correlations is 
      limited, and the evidence to assess the causality of these disease correlations 
      remains unclear. Future research should focus on the causality of disease links 
      in order to provide more decisive evidence with respect to the design of 
      intersectoral care processes.
FAU - Seitz, Max W
AU  - Seitz MW
AD  - Institute of Medical Biometry and Informatics, University of Heidelberg, 
      Marsilius-Arkaden Turm West, Im Neuenheimer Feld 130.3, D-69120 Heidelberg, 
      Germany. E-mail: max.seitz@med.uni-heidelberg.de.
FAU - Listl, Stefan
AU  - Listl S
AD  - Section for Translational Health Economics, Department of Conservative Dentistry, 
      Heidelberg University, Heidelberg, Germany.
AD  - Radboud University Medical Center, Radboud Institute for Health Sciences, 
      Department of Dentistry - Quality and Safety of Oral Healthcare, Nijmegen, The 
      Netherlands.
FAU - Bartols, Andreas
AU  - Bartols A
AD  - Dental Academy for Continuing Professional Development, Karlsruhe, Germany.
AD  - Christian-Albrechts-University Kiel, Clinic for Conservative Dentistry and 
      Periodontology, Kiel, Germany.
FAU - Schubert, Ingrid
AU  - Schubert I
AD  - PMV Research Group, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Blaschke, Katja
AU  - Blaschke K
AD  - PMV Research Group, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, Cologne, Germany.
FAU - Haux, Christian
AU  - Haux C
AD  - University of Heidelberg, Institute of Medical Biometry and Informatics, 
      Heidelberg, Germany.
FAU - Van Der Zande, Marieke M
AU  - Van Der Zande MM
AD  - Section for Translational Health Economics, Department of Conservative Dentistry, 
      Heidelberg University, Heidelberg, Germany.
AD  - Radboud University Medical Center, Radboud Institute for Health Sciences, 
      Department of Dentistry - Quality and Safety of Oral Healthcare, Nijmegen, The 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190926
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Coronary Disease/*complications
MH  - Dental Caries/*complications
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - Periodontal Diseases/*complications
MH  - Stroke/*complications
PMC - PMC6795069
EDAT- 2019/09/29 06:00
MHDA- 2020/07/03 06:00
PMCR- 2019/01/01
CRDT- 2019/09/28 06:00
PHST- 2019/09/28 06:00 [entrez]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2020/07/03 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - E132 [pii]
AID - 18_0641 [pii]
AID - 10.5888/pcd16.180641 [doi]
PST - epublish
SO  - Prev Chronic Dis. 2019 Sep 26;16:E132. doi: 10.5888/pcd16.180641.