PMID- 31560947
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 123
IP  - 6
DP  - 2019 Dec
TI  - The "envirome" and what the practitioner needs to know about it.
PG  - 542-549
LID - S1081-1206(19)31192-5 [pii]
LID - 10.1016/j.anai.2019.09.014 [doi]
AB  - OBJECTIVE: This review on the "envirome" focuses on pollution, microbial, and 
      social stressor elements of the environment that may impact development or 
      expression of allergic diseases. DATA SOURCES: Peer-reviewed publications on the 
      impact of environmental factors indexed in PubMed were the primary data source 
      for this review. STUDY SELECTIONS: The primary search strategy for this review 
      employed cross-referencing asthma, atopic dermatitis, and immunoglobulin E (IgE) 
      against pollution (ozone, particulate matter, nitrogen oxides, tobacco smoke), 
      microbial exposures (farm exposure, microbiome, infection, antibiotic use) and 
      psychosocial stressors, with emphasis on results in the past 5 years, with 
      inclusion of key seminal articles or comprehensive reviews. RESULTS: Air 
      pollution is a clear cause of allergic disease exacerbation, with increasing 
      recognition that pollutant exposure increases risk of allergic disease. Microbial 
      exposures and maternal and child stress also modulate development and expression 
      of allergic disease. Early life exposures are especially critical periods during 
      which all of these factors have notable impacts on allergic disease. CONCLUSION: 
      Nonallergenic environmental factors are important modulators and adjuvants for 
      development of allergic disease, with early life exposures being especially 
      important. Development and validation of interventions directed toward these 
      factors during early life is a significant opportunity for primary prevention of 
      allergic disease.
CI  - Copyright (c) 2019 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Peden, David B
AU  - Peden DB
AD  - The Center for Environmental Medicine, Asthma and Lung Biology and Division of 
      Allergy, Immunology and Rheumatology, Department of Pediatrics, the School of 
      Medicine, The University of North Carolina at Chapel Hill. Electronic address: 
      peden@med.unc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20190924
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Environmental Pollutants)
SB  - IM
CIN - Ann Allergy Asthma Immunol. 2019 Dec;123(6):532-533. PMID: 31761012
MH  - Anti-Bacterial Agents
MH  - *Environment
MH  - *Environmental Pollutants
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Incidence
MH  - Infections/epidemiology
MH  - Stress, Physiological
EDAT- 2019/09/29 06:00
MHDA- 2020/03/10 06:00
CRDT- 2019/09/28 06:00
PHST- 2019/08/22 00:00 [received]
PHST- 2019/09/14 00:00 [revised]
PHST- 2019/09/17 00:00 [accepted]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/09/28 06:00 [entrez]
AID - S1081-1206(19)31192-5 [pii]
AID - 10.1016/j.anai.2019.09.014 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2019 Dec;123(6):542-549. doi: 
      10.1016/j.anai.2019.09.014. Epub 2019 Sep 24.