PMID- 31561640
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 11
IP  - 10
DP  - 2019 Sep 26
TI  - Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating 
      Nanofibrous Drug Delivery Systems.
LID - 10.3390/pharmaceutics11100495 [doi]
LID - 495
AB  - We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to 
      generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and 
      biomedical applications. Traditional electrospinning (TES) equipped with a 
      conventional spinneret was used as a reference method. High-molecular 
      polyethylene oxide (PEO) and chitosan were used as carrier polymers and 
      theophylline anhydrate as a water-soluble model drug. The nanofibers were 
      electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and 
      formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber 
      diameter and morphology of the nanofibrous DDSs were modulated by varying 
      ultrasonic parameters in the USES process (i.e., frequency, pulse repetition 
      frequency and cycles per pulse). We found that the USES technology produced 
      nanofibers with higher fiber diameter (402 +/- 127 nm) than TES (77 +/- 21 nm). An 
      increase of a burst count in USES increased the fiber diameter (555 +/- 265 nm) and 
      the variation in fiber size. The slight-to-moderate changes in a solid state 
      (crystallinity) were detected when compared the nanofibers generated by TES and 
      USES. In conclusion, USES provides a promising alternative for aqueous-based 
      fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications.
FAU - Hakkarainen, Enni
AU  - Hakkarainen E
AD  - School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland. 
      hakkarainen.enni@gmail.com.
FAU - Korkjas, Arle
AU  - Korkjas A
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. arle.korkjas@ut.ee.
FAU - Laidmae, Ivo
AU  - Laidmae I
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. ivo.laidmae@ut.ee.
AD  - Department of Immunology, Institute of Biomedicine and Translational Medicine, 
      University of Tartu, Tartu 50411, Estonia. ivo.laidmae@ut.ee.
FAU - Lust, Andres
AU  - Lust A
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. andres.lust@ut.ee.
FAU - Semjonov, Kristian
AU  - Semjonov K
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. kristian.semjonov@gmail.com.
FAU - Kogermann, Karin
AU  - Kogermann K
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. kkogermann@gmail.com.
FAU - Nieminen, Heikki J
AU  - Nieminen HJ
AD  - Electronics Research Laboratory, Department of Physics, University of Helsinki, 
      00014 Helsinki, Finland. heikki.j.nieminen@aalto.fi.
AD  - Medical Ultrasonics Laboratory, Department of Neuroscience and Biomedical 
      Engineering, Aalto University, 02150 Espoo, Finland. heikki.j.nieminen@aalto.fi.
FAU - Salmi, Ari
AU  - Salmi A
AD  - Electronics Research Laboratory, Department of Physics, University of Helsinki, 
      00014 Helsinki, Finland. ari.salmi@helsinki.fi.
FAU - Korhonen, Ossi
AU  - Korhonen O
AD  - School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland. 
      ossi.korhonen@uef.fi.
FAU - Haeggstrom, Edward
AU  - Haeggstrom E
AD  - Electronics Research Laboratory, Department of Physics, University of Helsinki, 
      00014 Helsinki, Finland. edward.haeggstrom@helsinki.fi.
FAU - Heinamaki, Jyrki
AU  - Heinamaki J
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, 
      Estonia. jyrki.heinamaki@ut.ee.
LA  - eng
GR  - IUT34-18/Eesti Teadusagentuur/
GR  - PUT1088/Eesti Teadusagentuur/
PT  - Journal Article
DEP - 20190926
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC6835569
OTO - NOTNLM
OT  - nanotechnology, nanofibers, traditional electrospinning, ultrasound-enhanced 
      electrospinning, drug delivery system
COIS- The authors declare no conflicts of interest.
EDAT- 2019/09/29 06:00
MHDA- 2019/09/29 06:01
PMCR- 2019/10/01
CRDT- 2019/09/29 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/09/19 00:00 [revised]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/09/29 06:00 [entrez]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2019/09/29 06:01 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - pharmaceutics11100495 [pii]
AID - pharmaceutics-11-00495 [pii]
AID - 10.3390/pharmaceutics11100495 [doi]
PST - epublish
SO  - Pharmaceutics. 2019 Sep 26;11(10):495. doi: 10.3390/pharmaceutics11100495.