PMID- 31562631
OWN - NLM
STAT- MEDLINE
DCOM- 20191002
LR  - 20191007
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1161
DP  - 2019
TI  - Bioactive Lipids in Cancer, Inflammation and Related Diseases : Acute and Chronic 
      Mild Traumatic Brain Injury Differentially Changes Levels of Bioactive Lipids in 
      the CNS Associated with Headache.
PG  - 193-217
LID - 10.1007/978-3-030-21735-8_16 [doi]
AB  - Headache is a common complaint after mild traumatic brain injury (mTBI). Changes 
      in the CNS lipidome were previously associated with acrolein-induced headache in 
      rodents. mTBI caused similar headache-like symptoms in rats; therefore, we tested 
      the hypothesis that mTBI might likewise alter the lipidome. Using a stereotaxic 
      impactor, rats were given either a single mTBI or a series of 4 mTBIs 48 h apart. 
      72 h later for single mTBI and 7 days later for repeated mTBI, the trigeminal 
      ganglia (TG), trigeminal nucleus (TNC), and cerebellum (CER) were isolated. Using 
      HPLC/MS/MS, ~80 lipids were measured in each tissue and compared to sham 
      controls. mTBI drove widespread alterations in lipid levels. Single mTBI 
      increased arachidonic acid and repeated mTBI increased prostaglandins in all 3 
      tissue types. mTBI affected multiple TRPV agonists, including N-arachidonoyl 
      ethanolamine (AEA), which increased in the TNC and CER after single mTBI. After 
      repeated mTBI, AEA increased in the TG, but decreased in the TNC. Common to all 
      tissue types in single and repeated mTBI was an increase the AEA metabolite, 
      N-arachidonoyl glycine, a potent activator of microglial migration. Changes in 
      the CNS lipidome associated with mTBI likely play a role in headache and in 
      long-term neurodegenerative effects of repeated mTBI.
FAU - Leishman, Emma
AU  - Leishman E
AD  - Department of Psychological and Brain Sciences, Indiana University, Bloomington, 
      IN, USA.
FAU - Kunkler, Phillip E
AU  - Kunkler PE
AD  - Stark Neurosciences Institute, Indiana University School of Medicine, 
      Indianapolis, IN, USA.
FAU - Hurley, Joyce H
AU  - Hurley JH
AD  - Stark Neurosciences Institute, Indiana University School of Medicine, 
      Indianapolis, IN, USA.
FAU - Miller, Sally
AU  - Miller S
AD  - Department of Psychological and Brain Sciences, Indiana University, Bloomington, 
      IN, USA.
FAU - Bradshaw, Heather B
AU  - Bradshaw HB
AD  - Department of Psychological and Brain Sciences, Indiana University, Bloomington, 
      IN, USA. hbbradsh@indiana.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - *Brain Injuries, Traumatic/physiopathology
MH  - *Central Nervous System/physiopathology
MH  - *Headache/physiopathology
MH  - *Inflammation/physiopathology
MH  - *Lipids/chemistry/genetics/physiology
MH  - *Neoplasms/physiopathology
MH  - Rats
OTO - NOTNLM
OT  - Acyl amide
OT  - Acyl amino acid
OT  - BV-2
OT  - Docosahexaenoyl ethanolamine
OT  - Endocannabinoids
OT  - Lipidomics
OT  - Lipoamine
OT  - N-arachidonoyl glycine
OT  - TRP
OT  - mTBI
EDAT- 2019/09/29 06:00
MHDA- 2019/10/08 06:00
CRDT- 2019/09/29 06:00
PHST- 2019/09/29 06:00 [entrez]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
AID - 10.1007/978-3-030-21735-8_16 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2019;1161:193-217. doi: 10.1007/978-3-030-21735-8_16.