PMID- 31562867
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20211204
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 863
DP  - 2019 Nov 15
TI  - TRIB3 promotes lung cancer progression by activating beta-catenin signaling.
PG  - 172697
LID - S0014-2999(19)30649-1 [pii]
LID - 10.1016/j.ejphar.2019.172697 [doi]
AB  - TRIB3 roles in tumor progression have been revealed with similar or opposite 
      results. Here, we found that TRIB3 expression was highly expressed in lung cancer 
      tissues and correlated with tumor grades and metastasis. Functional experiments 
      showed that TRIB3 knockdown (KD) inhibited lung cancer cell migration, invasion, 
      EMT (epithelial-mesenchymal transition) process and stemness. Mechanistic studies 
      demonstrated that TRIB3 physically interacted with beta-catenin and increased the 
      recruitment of beta-catenin to the promoter region of genes regulated by Wnt. 
      Re-activation of beta-catenin attenuated the inhibition of TRIB3 KD on lung cancer 
      progression. These results suggest that TRIB3 interacts with beta-catenin and thus 
      activates beta-catenin signaling, which is responsible for lung cancer progression, 
      and blocking TRIB3 activity might be developed to treat lung cancer.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhang, Xiaochuan
AU  - Zhang X
AD  - Department of Cardio-Thoracic Surgery, The First People's Hospital of Kunshan, 91 
      Qianjin West Road, Kunshan, Jiangsu, 215300, PR China.
FAU - Zhong, Ning
AU  - Zhong N
AD  - Department of Cardio-Thoracic Surgery, The First People's Hospital of Kunshan, 91 
      Qianjin West Road, Kunshan, Jiangsu, 215300, PR China.
FAU - Li, Xing
AU  - Li X
AD  - Department of Cardio-Thoracic Surgery, The First People's Hospital of Kunshan, 91 
      Qianjin West Road, Kunshan, Jiangsu, 215300, PR China.
FAU - Chen, Min-Bin
AU  - Chen MB
AD  - Department of Radiotherapy & Oncology, The Affiliated Kunshan Hospital of Jiangsu 
      University, Kunsan, 215300, Jiangsu Province, China. Electronic address: 
      cmb19811@21cn.com.
LA  - eng
PT  - Journal Article
DEP - 20190925
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (TRIB3 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Cell Adhesion
MH  - Cell Cycle Proteins/deficiency/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Epithelial-Mesenchymal Transition
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Lung Neoplasms/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplastic Stem Cells/pathology
MH  - Protein Serine-Threonine Kinases/*antagonists & 
      inhibitors/deficiency/genetics/metabolism
MH  - Repressor Proteins/deficiency/genetics/*metabolism
MH  - *Wnt Signaling Pathway
OTO - NOTNLM
OT  - Invasion
OT  - Lung cancer
OT  - Migration
OT  - Stemness
OT  - TRIB3
OT  - beta-catenin
EDAT- 2019/09/29 06:00
MHDA- 2020/03/24 06:00
CRDT- 2019/09/29 06:00
PHST- 2019/04/29 00:00 [received]
PHST- 2019/09/23 00:00 [revised]
PHST- 2019/09/24 00:00 [accepted]
PHST- 2019/09/29 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/09/29 06:00 [entrez]
AID - S0014-2999(19)30649-1 [pii]
AID - 10.1016/j.ejphar.2019.172697 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2019 Nov 15;863:172697. doi: 10.1016/j.ejphar.2019.172697. Epub 
      2019 Sep 25.