PMID- 31564705
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200211
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 59
IP  - 10
DP  - 2019 Oct 26
TI  - [Guillain-Barre syndrome with refractory optic neuropathy].
PG  - 652-658
LID - 10.5692/clinicalneurol.cn-001329 [doi]
AB  - A 60-year-old woman with a 3-day history of ataxic gait, blurred vision, and 
      upper extremity paresthesia was admitted to our hospital. She presented with 
      severe visual disturbances (finger counting), ophthalmoplegia, neck weakness, and 
      sensory ataxia. Serum anti-GQ1b antibody, anti-GM3 antibody, and anti-GD3 
      antibody were strongly positive, which might contribute to the pathogenesis. 
      Since we suspected Guillain-Barre syndrome (GBS), intravenous immunoglobulin 
      therapy (IVIg) and high-dose steroid therapy were administered; however, 
      improvements in her visual acuity were minimal. Additional IVIg and high-dose 
      steroid therapy resulted in limited visual acuity improvements. Therapeutic 
      strategies for patients with GBS and refractory optic neuropathy remain 
      controversial.
FAU - Takeuchi, Yosuke
AU  - Takeuchi Y
AD  - Department of Neurology, Saiseikai Kumamoto Hospital.
AD  - Department of Neurology, National Hospital Organization Kumamotominami National 
      Hospital.
FAU - Inatomi, Yuichiro
AU  - Inatomi Y
AD  - Department of Neurology, Saiseikai Kumamoto Hospital.
FAU - Nakajima, Makoto
AU  - Nakajima M
AD  - Department of Neurology, Graduate School of Medical Sciences, Kumamoto 
      University.
FAU - Yonehara, Toshiro
AU  - Yonehara T
AD  - Department of Neurology, Saiseikai Kumamoto Hospital.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
DEP - 20190928
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (G(M3) Ganglioside)
RN  - 0 (Gangliosides)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 62010-37-1 (ganglioside, GD3)
RN  - 68652-37-9 (GQ1b ganglioside)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - Female
MH  - G(M3) Ganglioside/immunology
MH  - Gangliosides/immunology
MH  - Guillain-Barre Syndrome/*complications/diagnosis/*drug therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage
MH  - Methylprednisolone/administration & dosage
MH  - Middle Aged
MH  - Optic Nerve Diseases/diagnosis/*drug therapy/*etiology
MH  - Pulse Therapy, Drug
OTO - NOTNLM
OT  - Guillain-Barre syndrome
OT  - anti-GQ1b antibody
OT  - intravenous immunoglobulin therapy
OT  - optic neuropathy
EDAT- 2019/10/01 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/10/01 06:00
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
AID - 10.5692/clinicalneurol.cn-001329 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2019 Oct 26;59(10):652-658. doi: 
      10.5692/clinicalneurol.cn-001329. Epub 2019 Sep 28.