PMID- 31565109
OWN - NLM
STAT- MEDLINE
DCOM- 20200128
LR  - 20200128
IS  - 1918-1523 (Electronic)
IS  - 1203-6765 (Print)
IS  - 1203-6765 (Linking)
VI  - 2019
DP  - 2019
TI  - Effects of MRgFUS Treatment on Musculoskeletal Pain: Comparison between Bone 
      Metastasis and Chronic Knee/Lumbar Osteoarthritis.
PG  - 4867904
LID - 10.1155/2019/4867904 [doi]
LID - 4867904
AB  - Local bone denervation by magnetic resonance-guided focused ultrasound (MRgFUS) 
      is a promising tool for alleviation of pain in patients with painful bone 
      metastasis (BM). Considering the underlying mechanism of pain alleviation, MRgFUS 
      might be effective for various bone and joint diseases associated with local 
      tenderness. This study was conducted to clarify the therapeutic effect of focused 
      ultrasound in patients with various painful bone and joint diseases that are 
      associated with local tenderness. Ten patients with BM, 11 patients with lumbar 
      facet joint osteoarthritis (L-OA), and 19 patients with knee osteoarthritis 
      (K-OA) were included. MRgFUS treatment was applied to the bone surface with 
      real-time temperature monitoring at the target sites. Pain intensity was assessed 
      using a 100 mm numerical rating scale (NRS) at various time points. Pressure pain 
      threshold (PPT) was evaluated on the sonication area and control sites. Compared 
      to baseline, the pain NRS scores significantly decreased in all groups 1 month 
      after treatment, and PPT at the treated sites significantly increased in all 
      groups 3 months after treatment. The percentage of patients who showed a >/= 50% 
      decrease in pain NRS scores at 1 month after treatment was 80% in BM, 64% in 
      L-OA, and 78% in K-OA groups. PPTs were significantly higher after treatment at 
      all evaluation time points. This study indicated that MRgFUS is effective in 
      reducing pressure pain at the site of most severe tenderness in patients with 
      painful bone and joint diseases. Treatment response was comparable between 
      patients with BM, L-OA, and K-OA.
CI  - Copyright (c) 2019 Hirofumi Namba et al.
FAU - Namba, Hirofumi
AU  - Namba H
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku, Kochi 783-8505, Japan.
FAU - Kawasaki, Motohiro
AU  - Kawasaki M
AUID- ORCID: 0000-0002-9189-4577
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku, Kochi 783-8505, Japan.
AD  - Pain Medical Center, Shikoku Medical Center for Children and Adults, Zentsuji, 
      Kagawa 765-8507, Japan.
FAU - Izumi, Masashi
AU  - Izumi M
AUID- ORCID: 0000-0002-8592-6069
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku, Kochi 783-8505, Japan.
FAU - Ushida, Takahiro
AU  - Ushida T
AD  - Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, 
      Nagakute, Aichi 480-1195, Japan.
FAU - Takemasa, Ryuichi
AU  - Takemasa R
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku, Kochi 783-8505, Japan.
FAU - Ikeuchi, Masahiko
AU  - Ikeuchi M
AUID- ORCID: 0000-0003-4493-3657
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku, Kochi 783-8505, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20190902
PL  - United States
TA  - Pain Res Manag
JT  - Pain research & management
JID - 9612504
SB  - IM
MH  - Aged
MH  - Bone Neoplasms/secondary/therapy
MH  - Cancer Pain/*therapy
MH  - Female
MH  - High-Intensity Focused Ultrasound Ablation/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Musculoskeletal Pain/*etiology/*therapy
MH  - Osteoarthritis, Knee/complications/*therapy
MH  - Osteoarthritis, Spine/complications/*therapy
PMC - PMC6745150
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2019/10/01 06:00
MHDA- 2020/01/29 06:00
PMCR- 2019/09/02
CRDT- 2019/10/01 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/06/14 00:00 [revised]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/01/29 06:00 [medline]
PHST- 2019/09/02 00:00 [pmc-release]
AID - 10.1155/2019/4867904 [doi]
PST - epublish
SO  - Pain Res Manag. 2019 Sep 2;2019:4867904. doi: 10.1155/2019/4867904. eCollection 
      2019.