PMID- 31565673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2391-5463 (Print)
IS  - 2391-5463 (Electronic)
VI  - 14
DP  - 2019
TI  - The Factors Affecting Early Death in Newly Diagnosed APL Patients.
PG  - 647-652
LID - 10.1515/med-2019-0074 [doi]
AB  - BACKGROUND AND AIM: In the past, acute promyelocytic leukemia (APL) was 
      considered as one of the most rapidly lethal form of acute myeloid leukemia 
      (AML). The objective of this study was to assess clinical parameters affecting 
      early death (ED) in patients with APL. MATERIALS AND METHODS: Forty-three 
      patients with APL who were diagnosed at Hacettepe University Hospital between the 
      years of 2005 and 2018 were evaluated. RESULTS: In univariate analyses, 
      presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance 
      score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, 
      fibrinogen and LDH levels were found to be statistically significantly different 
      between patients with ER and patients without ED. In multivariate analysis, 
      presentation with hemorrhage, DIC or infection at diagnosis, ECOG performance 
      score, blast percentage on bone marrow, Sanz score, leukocyte, thrombocyte, 
      fibrinogen, and LDH levels were found to be independent factors that are related 
      with higher rate of ED in 30 days after treatment. CONCLUSION: Induction 
      chemotherapy should be started as soon as possible after diagnosis of APL. 
      Improving ED rates may become the greatest challenge for the future treatment of 
      the diseases.
CI  - (c) 2019 Rafiye Ciftciler et al. published by De Gruyter.
FAU - Ciftciler, Rafiye
AU  - Ciftciler R
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
FAU - Haznedaroglu, Ibrahim Celalettin
AU  - Haznedaroglu IC
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
FAU - Aksu, Salih
AU  - Aksu S
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
FAU - Ozcebe, Osman
AU  - Ozcebe O
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
FAU - Sayinalp, Nilgun
AU  - Sayinalp N
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
FAU - Malkan, Umit Yavuz
AU  - Malkan UY
AD  - Diskapi Education and Research Hospital, Department of Hematology, Ankara, 
      Turkey.
FAU - Buyukasik, Yahya
AU  - Buyukasik Y
AD  - Hacettepe University Faculty of Medicine, Department of Hematology; Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190912
PL  - Poland
TA  - Open Med (Wars)
JT  - Open medicine (Warsaw, Poland)
JID - 101672167
PMC - PMC6744608
OTO - NOTNLM
OT  - Acute promyelocytic leukemia
OT  - All-trans retinoic acid
OT  - Disseminated intravascular coagulation
COIS- Conflict of interest Conflict of interests: The authors of this paper have no 
      conflict of interests, including specific financial interests, relationships, 
      and/or affiliations relevant to the subject matter or materials included.
EDAT- 2019/10/01 06:00
MHDA- 2019/10/01 06:01
PMCR- 2019/09/12
CRDT- 2019/10/01 06:00
PHST- 2019/04/21 00:00 [received]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2019/10/01 06:01 [medline]
PHST- 2019/09/12 00:00 [pmc-release]
AID - med-2019-0074 [pii]
AID - 10.1515/med-2019-0074 [doi]
PST - epublish
SO  - Open Med (Wars). 2019 Sep 12;14:647-652. doi: 10.1515/med-2019-0074. eCollection 
      2019.