PMID- 31565735
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Print)
IS  - 2047-2404 (Linking)
VI  - 21
IP  - 6
DP  - 2020 Jun 1
TI  - Cardiovascular risk scoring and magnetic resonance imaging detected subclinical 
      cerebrovascular disease.
PG  - 692-700
LID - 10.1093/ehjci/jez226 [doi]
AB  - AIMS: Cardiovascular risk factors are used for risk stratification in primary 
      prevention. We sought to determine if simple cardiac risk scores are associated 
      with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular 
      disease including carotid wall volume (CWV), carotid intraplaque haemorrhage 
      (IPH), and silent brain infarction (SBI). METHODS AND RESULTS: A total of 7594 
      adults with no history of cardiovascular disease (CVD) underwent risk factor 
      assessment and a non-contrast enhanced MRI of the carotid arteries and brain 
      using a standardized protocol in a population-based cohort recruited between 2014 
      and 2018. The non-lab-based INTERHEART risk score (IHRS) was calculated in all 
      participants; the Framingham Risk Score was calculated in a subset who provided 
      blood samples (n = 3889). The association between these risk scores and MRI 
      measures of CWV, carotid IPH, and SBI was determined. The mean age of the cohort 
      was 58 (8.9) years, 55% were women. Each 5-point increase ( approximately 1 SD) in the IHRS was 
      associated with a 9 mm3 increase in CWV, adjusted for sex (P < 0.0001), a 23% 
      increase in IPH [95% confidence interval (CI) 9-38%], and a 32% (95% CI 20-45%) 
      increase in SBI. These associations were consistent for lacunar and non-lacunar 
      brain infarction. The Framingham Risk Score was also significantly associated 
      with CWV, IPH, and SBI. CWV was additive and independent to the risk scores in 
      its association with IPH and SBI. CONCLUSION: Simple cardiovascular risk scores 
      are significantly associated with the presence of MRI-detected subclinical 
      cerebrovascular disease, including CWV, IPH, and SBI in an adult population 
      without known clinical CVD.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Anand, Sonia S
AU  - Anand SS
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
AD  - Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, 
      Ontario L8S 4K1, Canada.
FAU - Tu, Jack V
AU  - Tu JV
AD  - Department of Medicine, University of Toronto, ICES, Sunnybrook Schulich Heart 
      Centre; 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada.
FAU - Desai, Dipika
AU  - Desai D
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
FAU - Awadalla, Phillip
AU  - Awadalla P
AD  - Department of Molecular Genetics, Ontario Institute for Cancer Research, 
      University of Toronto, 661 University Avenue Suite 510, Toronto, Ontario M5G 0A3, 
      Canada.
FAU - Robson, Paula
AU  - Robson P
AD  - Cancer Research and Analytics, Cancer Control Alberta, Alberta Health Services, 
      Suite 1500 Sun Life Place, 10123 99th Street NW, Edmonton, Alberta T5J 3H1, 
      Canada.
FAU - Jacquemont, Sebastien
AU  - Jacquemont S
AD  - Department of Medicine, Universite de Montreal, CHU Sainte Justine; 3175 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.
AD  - Department of Pediatrics, Universite de Montreal, CHU Sainte Justine, 3175 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.
FAU - Dummer, Trevor
AU  - Dummer T
AD  - School of Population and Public Health, University of British Columbia, 675 W 
      10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
FAU - Le, Nhu
AU  - Le N
AD  - Department of Statistics, BC Cancer Agency, University of British Columbia, 675 W 
      10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
FAU - Parker, Louise
AU  - Parker L
AD  - Department of Medicine, Dalhousie University; 1494 Carlton Street, P.O. Box 
      15000, Halifax, Nova Scotia B3H 4R2, Canada.
FAU - Poirier, Paul
AU  - Poirier P
AD  - Institut universitaire de cardiologie et de pneumologie de Quebec - Universite 
      Laval, 2725 chemin Sainte-Foy, Quebec G1V 4G5, Canada.
FAU - Teo, Koon
AU  - Teo K
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
AD  - Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, 
      Ontario L8S 4K1, Canada.
FAU - Lear, Scott A
AU  - Lear SA
AD  - Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, 
      Burnaby, British Columbia V5A 1S6, Canada.
FAU - Yusuf, Salim
AU  - Yusuf S
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
AD  - Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, 
      Ontario L8S 4K1, Canada.
FAU - Tardif, Jean-Claude
AU  - Tardif JC
AD  - Research Centre, Montreal Heart Institute, Universite de Montreal, 5000 Belanger 
      Street, Montreal H1T 1C8, Quebec, Canada.
FAU - Marcotte, Francois
AU  - Marcotte F
AD  - Research Centre, Montreal Heart Institute, Universite de Montreal, 5000 Belanger 
      Street, Montreal H1T 1C8, Quebec, Canada.
FAU - Busseuil, David
AU  - Busseuil D
AD  - Research Centre, Montreal Heart Institute, Universite de Montreal, 5000 Belanger 
      Street, Montreal H1T 1C8, Quebec, Canada.
FAU - Despres, Jean-Pierre
AU  - Despres JP
AD  - Department of Kinesiology, Universite Laval, 2325 rue de l'Universite, Quebec, 
      Quebec G1V 0A6, Canada.
FAU - Black, Sandra E
AU  - Black SE
AD  - Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, University 
      of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
AD  - Hurvitz Brain Sciences Research Program Director, Sunnybrook Research Institute, 
      Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, 
      Toronto, Ontario M4N 3M5, Canada.
FAU - Kirpalani, Anish
AU  - Kirpalani A
AD  - Department of Medical Imaging, St. Michael's Hospital, University of Toronto, 30 
      Bond Street, Toronto, Ontario M5B 1W8, Canada.
FAU - Parraga, Grace
AU  - Parraga G
AD  - Department of Medical Biophysics, Western University, 1151 Richmond Street North, 
      London, Ontario N6A 5C1, Canada.
AD  - Robarts Research Institute, Western University, 1151 Richmond Street North, 
      London, Ontario N6A 5B7, Canada.
FAU - Noseworthy, Michael D
AU  - Noseworthy MD
AD  - Department of Electrical and Computer Engineering, School of Biomedical 
      Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 
      4K1, Canada.
AD  - Diagnostic Imaging, St. Joseph's Health Care, 50 Charlton Avenue East, Hamilton, 
      Ontario L8N 4A6, Canada.
FAU - Dick, Alexander
AU  - Dick A
AD  - Division of Cardiology, University of Ottawa Heart Institute, University of 
      Ottawa, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.
FAU - Leipsic, Jonathan
AU  - Leipsic J
AD  - Department of Radiology, University of British Columbia, St. Paul's Hospital, 
      1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada.
FAU - Kelton, David
AU  - Kelton D
AD  - Diagnostic Imaging, Brampton Civic Hospital, William Osler Health System, 2100 
      Bovaird Street East, Brampton, Ontario L6R 3J7, Canada.
FAU - Vena, Jennifer
AU  - Vena J
AD  - Cancer Research and Analytics, Cancer Control Alberta, Alberta Health Services, 
      Richmond Road Diagnostic and Treatment Centre, 1820 Richmond Road SW Calgary, 
      Alberta T2T 5C7, Canada.
FAU - Thomas, Melissa
AU  - Thomas M
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
FAU - Schulze, Karleen M
AU  - Schulze KM
AD  - Population Health Research Institute, Hamilton Health Sciences, McMaster 
      University, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
AD  - Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, 
      Ontario L8S 4K1, Canada.
FAU - Larose, Eric
AU  - Larose E
AD  - Institut universitaire de cardiologie et de pneumologie de Quebec - Universite 
      Laval, 2725 chemin Sainte-Foy, Quebec G1V 4G5, Canada.
FAU - Moody, Alan R
AU  - Moody AR
AD  - Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of 
      Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
FAU - Smith, Eric E
AU  - Smith EE
AD  - Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of 
      Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
FAU - Friedrich, Matthias G
AU  - Friedrich MG
AD  - Department of Medicine and Diagnostic Radiology, McGill University, 1001 Decarie 
      Boulevard, Montreal, Quebec H4A 3J1, Canada.
LA  - eng
GR  - FDN-143255/CAPMC/CIHR/Canada
GR  - FDN-143313/CAPMC/CIHR/Canada
GR  - FDN 154317/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Adult
MH  - *Cardiovascular Diseases/diagnostic imaging/epidemiology
MH  - *Cerebrovascular Disorders/diagnostic imaging/epidemiology
MH  - Female
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - *Plaque, Atherosclerotic
MH  - Risk Factors
PMC - PMC7237958
OTO - NOTNLM
OT  - atherosclerosis
OT  - magnetic resonance imaging
OT  - risk factors
OT  - silent brain infarction
EDAT- 2019/10/01 06:00
MHDA- 2021/06/29 06:00
PMCR- 2019/09/30
CRDT- 2019/10/01 06:00
PHST- 2019/03/14 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/08/21 00:00 [accepted]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/09/30 00:00 [pmc-release]
AID - 5575077 [pii]
AID - jez226 [pii]
AID - 10.1093/ehjci/jez226 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2020 Jun 1;21(6):692-700. doi: 
      10.1093/ehjci/jez226.