PMID- 31565875
OWN - NLM
STAT- MEDLINE
DCOM- 20200513
LR  - 20200513
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Print)
IS  - 2093-596X (Linking)
VI  - 34
IP  - 3
DP  - 2019 Sep
TI  - Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond.
PG  - 234-246
LID - 10.3803/EnM.2019.34.3.234 [doi]
AB  - Branched-chain amino acids (BCAAs) are essential amino acids that are not 
      synthesized in our body; thus, they need to be obtained from food. They have 
      shown to provide many physiological and metabolic benefits such as stimulation of 
      pancreatic insulin secretion, milk production, adipogenesis, and enhanced immune 
      function, among others, mainly mediated by mammalian target of rapamycin (mTOR) 
      signaling pathway. After identified as a reliable marker of obesity and type 2 
      diabetes in recent years, an increasing number of studies have surfaced 
      implicating BCAAs in the pathophysiology of other diseases such as cancers, 
      cardiovascular diseases, and even neurodegenerative disorders like Alzheimer's 
      disease. Here we discuss the most recent progress and review studies highlighting 
      both correlational and potentially causative role of BCAAs in the development of 
      these disorders. Although we are just beginning to understand the intricate 
      relationships between BCAAs and some of the most prevalent chronic diseases, 
      current findings raise a possibility that they are linked by a similar putative 
      mechanism.
CI  - Copyright (c) 2019 Korean Endocrine Society.
FAU - Siddik, Md Abu Bakkar
AU  - Siddik MAB
AUID- ORCID: 0000-0002-3550-946X
AD  - Department of Nutritional Sciences, College of Human Sciences, Texas Tech 
      University, Lubbock, TX, USA.
FAU - Shin, Andrew C
AU  - Shin AC
AUID- ORCID: 0000-0002-4748-5135
AD  - Department of Nutritional Sciences, College of Human Sciences, Texas Tech 
      University, Lubbock, TX, USA. andrew.shin@ttu.edu.
LA  - eng
GR  - DK099463/NH/NIH HHS/United States
GR  - TTU/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
RN  - 0 (Amino Acids, Branched-Chain)
SB  - IM
MH  - Alzheimer Disease/metabolism
MH  - Amino Acids, Branched-Chain/*metabolism
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Heart Diseases/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Neoplasms/metabolism
MH  - Obesity/*metabolism
MH  - Signal Transduction
PMC - PMC6769348
OTO - NOTNLM
OT  - Alzheimer disease
OT  - Branched-chain amino acids
OT  - Cancers
OT  - Heart failure
OT  - Metabolism
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2019/10/01 06:00
MHDA- 2020/05/14 06:00
PMCR- 2019/09/01
CRDT- 2019/10/01 06:00
PHST- 2019/08/15 00:00 [received]
PHST- 2019/09/16 00:00 [revised]
PHST- 2019/09/21 00:00 [accepted]
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/05/14 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - 34.234 [pii]
AID - 10.3803/EnM.2019.34.3.234 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2019 Sep;34(3):234-246. doi: 10.3803/EnM.2019.34.3.234.