PMID- 31566825
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20210208
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 12
DP  - 2019 Dec
TI  - Prognostic implications of human papillomavirus status and p16 expression in 
      laryngeal squamous cell carcinoma.
PG  - 4151-4163
LID - 10.1002/hed.25961 [doi]
AB  - BACKGROUND: The purpose of this study was to investigate significance of HPV16 
      DNA/p16 for survival of patients with laryngeal squamous cell carcinoma (LSCC). 
      METHODS: HPV16 DNA and p16 status in 812 LSCC patients were determined. The 
      survival was performed using Kaplan-Meier estimates and Cox model. RESULTS: 
      Compared with HPV negativity, adjusted HRs for HPV16 positivity were 0.57, 95% 
      CI, 0.38 to 0.87; 0.60, 0.40 to 0.88; and 0.65, 0.46 to 0.94 for disease-specific 
      survival (DSS), recurrence-free survival (RFS), and overall survival (OS), 
      respectively. Additionally, for p16 expression, aHRs were 0.68, 95% CI, 0.48 to 
      0.96; 0.72, 0.52 to 0.98; and 0.73, 0.54 to 0.99 for DSS, RFS, and OS, 
      respectively. Finally, for combined analysis, patients with both 
      HPV16-positivity/p16-positivity had much better prognosis than those with either 
      negativity. Such above survivals are more significantly better in never smokers. 
      CONCLUSION: Our findings suggest that HPV16/p16 may affect survival outcomes of 
      LSCC patients, particularly in never smokers.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Zhu, Yingying
AU  - Zhu Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, China.
FAU - Xia, Xin
AU  - Xia X
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, China.
FAU - Gross, Neil
AU  - Gross N
AD  - Department of Head and Neck Surgery, University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - Dahlstrom, Kristina R
AU  - Dahlstrom KR
AD  - Department of Head and Neck Surgery, University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - Gao, Liming
AU  - Gao L
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, China.
FAU - Liang, Zhiyong
AU  - Liang Z
AD  - Department of Pathology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Gao, Zhiqiang
AU  - Gao Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, China.
FAU - Wei, Peng
AU  - Wei P
AD  - Department of Biostatistics, University of Texas MD Anderson Cancer Center, 
      Houston, Texas.
FAU - Liu, Chuan
AU  - Liu C
AUID- ORCID: 0000-0003-0642-3154
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Li, Guojun
AU  - Li G
AUID- ORCID: 0000-0001-9505-1502
AD  - Department of Head and Neck Surgery, University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - Li, Yuncheng
AU  - Li Y
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Chen, Xingming
AU  - Chen X
AUID- ORCID: 0000-0002-9930-2185
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, China.
LA  - eng
GR  - 81273173/National Natural Science Foundation of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190930
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Squamous Cell/genetics/mortality/pathology/*virology
MH  - Cyclin-Dependent Kinase Inhibitor p16/genetics/*metabolism
MH  - DNA, Viral/*genetics
MH  - Female
MH  - Human papillomavirus 16/*genetics
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/mortality/pathology/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prognosis
MH  - Survival Rate
OTO - NOTNLM
OT  - human papillomavirus
OT  - laryngeal neoplasms
OT  - p16
OT  - prognosis
OT  - squamous cell carcinoma
EDAT- 2019/10/01 06:00
MHDA- 2020/08/05 06:00
CRDT- 2019/10/01 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/07/10 00:00 [revised]
PHST- 2019/08/28 00:00 [accepted]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
AID - 10.1002/hed.25961 [doi]
PST - ppublish
SO  - Head Neck. 2019 Dec;41(12):4151-4163. doi: 10.1002/hed.25961. Epub 2019 Sep 30.