PMID- 31566925
OWN - NLM
STAT- MEDLINE
DCOM- 20200907
LR  - 20200907
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 6
IP  - 10
DP  - 2019 Oct
TI  - Brain lesion distribution criteria distinguish demyelinating diseases in China.
PG  - 2048-2053
LID - 10.1002/acn3.50913 [doi]
AB  - OBJECTIVE: To verify the utility of brain lesion distribution criteria in 
      distinguishing multiple sclerosis (MS) from aquaporin-4 (AQP4)-immunoglobulin G 
      (IgG)-positive/-negative neuromyelitis optica spectrum disorder (NMOSD) and 
      myelin oligodendrocyte glycoprotein IgG-associated encephalomyelitis (MOG-EM) in 
      the Chinese population. METHODS: A total of 253 patients with MS (80), NMOSD (129 
      AQP4-IgG positive, 34 AQP4-IgG negative), and MOG-EM (10) were enrolled. 
      Anonymized magnetic resonance imaging results were scored on the previous 
      reported criteria of "at least one lesion adjacent to the body of the lateral 
      ventricle and in the inferior temporal lobe; or the presence of a subcortical 
      U-fiber lesion; or a Dawson's finger-type lesion." Chi-squared test (or Fisher's 
      exact test) was used to analyze the data. RESULTS: The distribution criteria were 
      able to distinguish MS with a same sensitivity of 93.8% from all type of NMOSD 
      and MOG-EM, with a specificity of 89.7% from the whole NMOSD cohort, 89.1% from 
      AQP4-IgG-positive NMOSD 91.2% from AQP4-IgG-negative NMOSD, and 70.0% from 
      MOG-EM. Dawson's finger-type lesion was the most sensitive and specific feature, 
      whereas the U-fiber lesion was the least. CONCLUSION: The brain lesion 
      distribution criteria were helpful in distinguishing MS from NMOSD and MOG-EM in 
      the Chinese population. Dawson's finger-type lesion was highly suggestive of MS.
CI  - (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by 
      Wiley Periodicals, Inc on behalf of American Neurological Association.
FAU - Cai, Meng-Ting
AU  - Cai MT
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Zhang, Yin-Xi
AU  - Zhang YX
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Zheng, Yang
AU  - Zheng Y
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Fang, Wei
AU  - Fang W
AD  - Department of Neurology, Fourth Affiliated Hospital, School of Medicine, Zhejiang 
      University, Yiwu, China.
FAU - Shen, Chun-Hong
AU  - Shen CH
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Ding, Mei-Ping
AU  - Ding MP
AUID- ORCID: 0000-0003-3145-7778
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
LA  - eng
GR  - 81671283/National Natural Science Foundation of China/International
GR  - 81701266/National Natural Science Foundation of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190930
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aquaporin 4/*immunology
MH  - Child
MH  - China
MH  - Demyelinating Autoimmune Diseases, CNS/*diagnostic imaging
MH  - Encephalomyelitis/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Lateral Ventricles/diagnostic imaging
MH  - Magnetic Resonance Imaging/methods/*standards
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging
MH  - Myelin-Oligodendrocyte Glycoprotein/*immunology
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Neuromyelitis Optica/*diagnostic imaging
MH  - Sensitivity and Specificity
MH  - Temporal Lobe/*diagnostic imaging
MH  - Young Adult
PMC - PMC6801206
COIS- The authors have no conflict of interest to report.
EDAT- 2019/10/01 06:00
MHDA- 2020/09/08 06:00
PMCR- 2019/09/30
CRDT- 2019/10/01 06:00
PHST- 2019/06/06 00:00 [received]
PHST- 2019/08/13 00:00 [revised]
PHST- 2019/09/08 00:00 [accepted]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/09/08 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/09/30 00:00 [pmc-release]
AID - ACN350913 [pii]
AID - 10.1002/acn3.50913 [doi]
PST - ppublish
SO  - Ann Clin Transl Neurol. 2019 Oct;6(10):2048-2053. doi: 10.1002/acn3.50913. Epub 
      2019 Sep 30.