PMID- 31567627
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20210125
IS  - 1948-8270 (Electronic)
IS  - 1948-8270 (Linking)
VI  - 27
IP  - 2
DP  - 2020 Apr
TI  - A Prospective Outcome Assessment After Bronchoscopic Interventions for Malignant 
      Central Airway Obstruction.
PG  - 95-105
LID - 10.1097/LBR.0000000000000624 [doi]
AB  - BACKGROUND: A systematic assessment of comprehensive clinical outcomes after 
      various therapeutic procedures for malignant central airway obstruction (CAO) is 
      lacking. METHODS: Patients with symptomatic malignant CAO undergoing various 
      therapeutic bronchoscopy procedures were assessed for symptomatic and functional 
      improvement using the Speiser Score, spirometry, 6-minute walk distance (6MWD), 
      and St. George Respiratory Questionnaire (SGRQ) up to 3 months after the 
      procedures. RESULTS: A total of 83 intervention procedures were performed in 65 
      patients, comprising 43 (66.2%) male individuals [overall mean age, 52.4; SD, 
      15.4 y]. The majority of these (92.3%) was done using rigid bronchoscope under 
      general anesthesia. Airway stenting was the most common intervention performed 
      (56.6%), followed by mechanical debulking (26.5%), cryodebulking (6%), 
      electrosurgical removal (4.8%), balloon dilatation (3.6%), and laser ablation 
      (2.4%).A total of 15 complications (18.1%) were noted. Of these, 8 (53.3%) were 
      early complications and 7 (46.7%) were late complications. Early complications 
      included airway bleeding, hypoxia, vocal cord injury, laryngeal injury, and 
      pneumothorax. Late complications included significant granulation tissue 
      formation in metallic stents and lung collapse because of mucus plug.The survival 
      rates at 4, 8, and 12 weeks were 83%, 70.7%, and 66.1%, respectively. Significant 
      improvement was observed in dyspnea, cough, Speiser Score, 6MWD, forced 
      expiratory volume in 1 s, forced vital capacity, and SGRQ scores at 48 hours, 4 
      weeks, and at 12 weeks after the procedures and no procedure-related mortality 
      occurred. CONCLUSION: Various therapeutic bronchoscopic interventions, including 
      combined modalities, provide rapid and sustained improvements in symptoms, 
      respiratory status, exercise capacity, and quality of life in malignant CAO and 
      have a good safety profile.
FAU - Mohan, Anant
AU  - Mohan A
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
FAU - Shrestha, Prajowl
AU  - Shrestha P
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
FAU - Madan, Karan
AU  - Madan K
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
FAU - Hadda, Vijay
AU  - Hadda V
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
FAU - Pandey, Ravindra M
AU  - Pandey RM
AD  - Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
FAU - Upadhyay, Ashish
AU  - Upadhyay A
AD  - Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
FAU - Khilnani, Gopi C
AU  - Khilnani GC
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
FAU - Guleria, Randeep
AU  - Guleria R
AD  - Departments of Pulmonary Medicine and Sleep Disorders.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Bronchology Interv Pulmonol
JT  - Journal of bronchology & interventional pulmonology
JID - 101496866
SB  - IM
MH  - Adult
MH  - Aged
MH  - Airway Obstruction/*diagnosis/etiology/*surgery
MH  - Bronchoscopy/*methods
MH  - Cytoreduction Surgical Procedures/adverse effects/methods
MH  - Dilatation/adverse effects/instrumentation
MH  - Electrosurgery/adverse effects/methods
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Laser Therapy/adverse effects/methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications/pathology
MH  - Prospective Studies
MH  - Quality of Life
MH  - Respiratory Function Tests/methods
MH  - Stents/adverse effects
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2019/10/01 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/10/01 06:00
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
AID - 01436970-202004000-00005 [pii]
AID - 10.1097/LBR.0000000000000624 [doi]
PST - ppublish
SO  - J Bronchology Interv Pulmonol. 2020 Apr;27(2):95-105. doi: 
      10.1097/LBR.0000000000000624.