PMID- 31568716 OWN - NLM STAT- MEDLINE DCOM- 20200608 LR - 20210110 IS - 2162-3279 (Electronic) VI - 9 IP - 12 DP - 2019 Dec TI - Aberrant patterns of default-mode network functional connectivity associated with metabolic syndrome: A resting-state study. PG - e01333 LID - 10.1002/brb3.1333 [doi] LID - e01333 AB - INTRODUCTION: Metabolic syndrome (MetS) is a clustering of three or more cardiovascular risk factors (RF), including hypertension, obesity, high cholesterol, or hyperglycemia. MetS and its component RFs are more prevalent in older age, and can be accompanied by alterations in brain structure. Studies have shown altered functional connectivity (FC) in samples with individual RFs as well as in clinical populations that are at higher risk to develop MetS. These studies have indicated that the default mode network (DMN) may be particularly vulnerable, yet little is known about the overall impact of MetS on FC in this network. METHODS: In this study, we evaluated the integrity of FC to the DMN in participants with MetS relative to non-MetS individuals. Using a seed-based connectivity analysis approach, resting-state functional MRI (fMRI) data were analyzed, and the FC measures among the DMN seed (isthmus of the cingulate) and rest of the brain voxels were estimated. RESULTS: Participants with MetS demonstrated reduced positive connectivity between the DMN seed and left superior frontal regions, and reduced negative connectivity between the DMN seed and left superior parietal, left postcentral, right precentral, right superior temporal and right superior parietal regions, after accounting for age- and sex-effects. CONCLUSIONS: Our results suggest that MetS is associated with alterations in FC between the DMN and other regions of the brain. Furthermore, these results indicate that the overall burden of vascular RFs associated with MetS may, in part, contribute to the pathophysiology underlying aberrant FC in the DMN. CI - Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Brain and Behavior published by Wiley Periodicals, Inc. FAU - Rashid, Barnaly AU - Rashid B AUID- ORCID: 0000-0002-3602-5109 AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Dev, Sheena I AU - Dev SI AD - Harvard Medical School, Boston, Massachusetts. AD - SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California. FAU - Esterman, Michael AU - Esterman M AUID- ORCID: 0000-0002-9000-3920 AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts. FAU - Schwarz, Nicolette F AU - Schwarz NF AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts. FAU - Ferland, Tori AU - Ferland T AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Fortenbaugh, Francesca C AU - Fortenbaugh FC AUID- ORCID: 0000-0002-8585-1589 AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Milberg, William P AU - Milberg WP AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - McGlinchey, Regina E AU - McGlinchey RE AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Salat, David H AU - Salat DH AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - The Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts. FAU - Leritz, Elizabeth C AU - Leritz EC AUID- ORCID: 0000-0002-6567-6605 AD - Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20190930 PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Aged MH - Brain Diseases/pathology/*physiopathology MH - Brain Mapping/methods MH - Female MH - Frontal Lobe/*physiopathology MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Metabolic Syndrome/pathology/*physiopathology MH - Middle Aged MH - Neural Pathways/physiopathology MH - Parietal Lobe/*physiopathology PMC - PMC6908882 OTO - NOTNLM OT - default mode network OT - functional connectivity OT - metabolic syndrome OT - resting-state fMRI OT - seed-based analysis COIS- The authors declare no competing financial interests in relation to the work presented. EDAT- 2019/10/01 06:00 MHDA- 2020/06/09 06:00 PMCR- 2019/09/30 CRDT- 2019/10/01 06:00 PHST- 2018/12/03 00:00 [received] PHST- 2019/03/13 00:00 [revised] PHST- 2019/03/29 00:00 [accepted] PHST- 2019/10/01 06:00 [pubmed] PHST- 2020/06/09 06:00 [medline] PHST- 2019/10/01 06:00 [entrez] PHST- 2019/09/30 00:00 [pmc-release] AID - BRB31333 [pii] AID - 10.1002/brb3.1333 [doi] PST - ppublish SO - Brain Behav. 2019 Dec;9(12):e01333. doi: 10.1002/brb3.1333. Epub 2019 Sep 30.