PMID- 31568767
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20201023
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1725
DP  - 2019 Dec 15
TI  - Opposed cannabinoid 1 receptor (CB1R) expression in the prefrontal cortex vs. 
      nucleus accumbens is associated with alcohol consumption in male rats.
PG  - 146485
LID - S0006-8993(19)30539-6 [pii]
LID - 10.1016/j.brainres.2019.146485 [doi]
AB  - Abusive alcohol consumption is a health problem, worldwide. There is extensive 
      literature indicating that cannabinoid 1 receptor (CB1R) plays a crucial role in 
      mediating alcohol's reward effects. Maternal care deprivation (MCD) is a reliable 
      rodent model of early life stress that leads to high levels of anxiety and 
      alterations in motivation, which may increase vulnerability to alcohol 
      consumption. The present study researched whether anxiety-like behaviors and the 
      level of motivation for a natural reward, and CB1R expression in the prefrontal 
      cortex (PFC) and nucleus accumbens (NAcc) can predict alcohol consumption in 
      non-MCD and MCD male rats. Results indicate that MCD increases anxiety-like 
      behaviors, i.e., reduces time in open arms in the elevated plus maze and 
      increases alcohol intake. In turn, the motivation for a palatable reward, i.e., a 
      chocolate flavored pellet, was not affected by MCD. MCD reduces CB1R expression 
      in the PFC and increases it in the NAcc. Hence, both higher anxiety-like 
      behaviors and higher CB1R expression in the NAcc and lower CB1R expression in the 
      PFC are associated with higher alcohol intake. These results suggest that early 
      life adverse experiences induce a reprogramming of the brain's endocannabinoid 
      system that very likely contributes to making the brain vulnerable to develop 
      alcohol abuse and dependence.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Amancio-Belmont, Octavio
AU  - Amancio-Belmont O
AD  - Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiologia, 
      Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Becerril Melendez, Alline L
AU  - Becerril Melendez AL
AD  - Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiologia, 
      Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Ruiz-Contreras, Alejandra E
AU  - Ruiz-Contreras AE
AD  - Grupo de Neurociencias, Laboratorio de Neurogenomica Cognitiva, Departamento de 
      Psicofisiologia, Facultad de Psicologia, Universidad Nacional Autonoma de Mexico, 
      Mexico.
FAU - Mendez-Diaz, Monica
AU  - Mendez-Diaz M
AD  - Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiologia, 
      Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Prospero-Garcia, Oscar
AU  - Prospero-Garcia O
AD  - Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiologia, 
      Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico. Electronic 
      address: opg@unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190927
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cnr1 protein, rat)
RN  - 0 (Receptor, Cannabinoid, CB1)
SB  - IM
MH  - Alcohol Drinking/*metabolism/psychology
MH  - Animals
MH  - Anxiety/etiology/*metabolism
MH  - Male
MH  - Maternal Deprivation
MH  - Motivation/physiology
MH  - Nucleus Accumbens/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Rats, Wistar
MH  - Receptor, Cannabinoid, CB1/*metabolism
MH  - *Reward
MH  - Stress, Psychological/complications
OTO - NOTNLM
OT  - Alcohol intake
OT  - Anxiety
OT  - Cannabinoid 1 receptor
OT  - Maternal care deprivation
OT  - Nucleus accumbens
OT  - Vulnerability
EDAT- 2019/10/01 06:00
MHDA- 2020/10/24 06:00
CRDT- 2019/10/01 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/09/24 00:00 [revised]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
PHST- 2019/10/01 06:00 [entrez]
AID - S0006-8993(19)30539-6 [pii]
AID - 10.1016/j.brainres.2019.146485 [doi]
PST - ppublish
SO  - Brain Res. 2019 Dec 15;1725:146485. doi: 10.1016/j.brainres.2019.146485. Epub 
      2019 Sep 27.