PMID- 31569158
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20210110
IS  - 1531-5487 (Electronic)
IS  - 1044-3983 (Print)
IS  - 1044-3983 (Linking)
VI  - 30 Suppl 2
IP  - Suppl 2
DP  - 2019 Nov
TI  - Exposure to Persistent Organic Pollutants and Birth Characteristics: The Upstate 
      KIDS Study.
PG  - S94-S100
LID - 10.1097/EDE.0000000000001095 [doi]
AB  - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) may be 
      associated with obesogenic effects in offspring. Our study is the first to 
      investigate associations between concentrations of POPs from newborn dried blood 
      spots (DBS) and birth characteristics. METHODS: Concentrations of 10 
      polychlorinated biphenyl congeners (PCBs), polybrominated diphenyl ether-47 
      (PBDE-47), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were measured 
      from DBSs collected at birth from 2,065 singleton infants. DBS samples were 
      pooled in groups of five and assayed together to reach limits of detection. 
      Differences in risk of large for gestational age (LGA, defined as >90th 
      percentile of birth weight for sex and gestational age), small for gestational 
      age (SGA, <10th), and preterm birth (gestational age <37 weeks) were estimated 
      using logistic regression per unit (ng/ml) increase in concentration of each 
      chemical, adjusting for individual-level covariates, including maternal age, 
      race/ethnicity, prepregnancy BMI, education, parity, smoking, and infant sex 
      while assuming a gamma distribution and using multiple imputation to account for 
      pools. RESULTS: There were 215 (11.3%) singletons born LGA, 158 (7.5%) born SGA, 
      and 157 (7.6%) born preterm. Higher concentrations of POPs were positively 
      associated with slightly higher risk of LGA and higher birth weight. CONCLUSIONS: 
      Relationships between POPs measured in newborn DBS and birth size were mixed. 
      Pooled analysis methods using DBS could address challenges in limits of detection 
      and costs for population-based research.
FAU - Bell, Griffith A
AU  - Bell GA
AD  - From the Division of Intramural Population Health Research, Eunice Kennedy 
      Shriver National Institute of Child Health and Human Development, National 
      Institutes of Health, Bethesda, MD.
FAU - Perkins, Neil
AU  - Perkins N
AD  - From the Division of Intramural Population Health Research, Eunice Kennedy 
      Shriver National Institute of Child Health and Human Development, National 
      Institutes of Health, Bethesda, MD.
FAU - Buck Louis, Germaine M
AU  - Buck Louis GM
AD  - From the Division of Intramural Population Health Research, Eunice Kennedy 
      Shriver National Institute of Child Health and Human Development, National 
      Institutes of Health, Bethesda, MD.
AD  - Dean's Office, College of Health and Human Services, George Mason University, 
      Fairfax, VA.
FAU - Kannan, Kurunthachalam
AU  - Kannan K
AD  - Wadsworth Center, New York State Department of Health, and Department of 
      Environmental Health Sciences, School of Public Health, State University of New 
      York at Albany, Albany, NY.
FAU - Bell, Erin M
AU  - Bell EM
AD  - Department of Environmental Health Services, University at Albany, State 
      University of New York, Albany, NY.
FAU - Gao, Chongjing
AU  - Gao C
AD  - Wadsworth Center, New York State Department of Health, and Department of 
      Environmental Health Sciences, School of Public Health, State University of New 
      York at Albany, Albany, NY.
FAU - Yeung, Edwina H
AU  - Yeung EH
AD  - From the Division of Intramural Population Health Research, Eunice Kennedy 
      Shriver National Institute of Child Health and Human Development, National 
      Institutes of Health, Bethesda, MD.
LA  - eng
GR  - Z99 HD999999/ImNIH/Intramural NIH HHS/United States
GR  - ZIA HD008826/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Epidemiology
JT  - Epidemiology (Cambridge, Mass.)
JID - 9009644
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Birth Weight/*drug effects
MH  - Dichlorodiphenyl Dichloroethylene/*adverse effects/blood
MH  - Dried Blood Spot Testing
MH  - Environmental Exposure/*adverse effects/statistics & numerical data
MH  - Environmental Pollutants/*adverse effects/blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/adverse effects/blood
MH  - Humans
MH  - Infant, Newborn/blood
MH  - Infant, Small for Gestational Age/blood
MH  - Logistic Models
MH  - Male
MH  - Maternal Age
MH  - Polychlorinated Biphenyls/*adverse effects/blood
MH  - Pregnancy
MH  - Premature Birth/blood/*epidemiology
MH  - Prenatal Exposure Delayed Effects/*epidemiology
PMC - PMC7047652
MID - NIHMS1563341
EDAT- 2019/10/01 06:00
MHDA- 2020/09/09 06:00
PMCR- 2020/05/01
CRDT- 2019/10/01 06:00
PHST- 2019/10/01 06:00 [entrez]
PHST- 2019/10/01 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 00001648-201911001-00013 [pii]
AID - 10.1097/EDE.0000000000001095 [doi]
PST - ppublish
SO  - Epidemiology. 2019 Nov;30 Suppl 2(Suppl 2):S94-S100. doi: 
      10.1097/EDE.0000000000001095.