PMID- 31569597 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 8 IP - 10 DP - 2019 Sep 27 TI - Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male. LID - 10.3390/jcm8101550 [doi] LID - 1550 AB - The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as geriatric adverse events (AEs), are unknown. This retrospective cohort study analyzed claims data collected during the period of 1997-2012 from Taiwan's Longitudinal Health Insurance Database 2000. Patients who received transurethral resection of the prostate (TURP) were prioritized, and the remaining patients who were prescribed alpha-blockers were, subsequently, identified. Patients in the TURP and medication-only groups were further divided into two groups, according to the presence or absence of AEs during the first six-month follow-up. Outcomes of primary interest were all-cause mortality, occurrence of prostate cancer, transurethral resection of the bladder tumor, and radical cystectomy for bladder cancer. Compared with patients in the AE-free TURP group, those in the TURP with AEs had a higher risk of lifelong bladder cancer (subdistribution hazard ratio: 2.3, 95% confidence interval (CI): 1.56-3.39), whereas the risk of prostate cancer was comparable between the two groups (SHR: 1.2, 95% CI: 0.83-1.74). In the medication cohorts, patients undergoing alpha-blocker treatment who had AEs had a higher risk of all-cause mortality (hazard ratio: 1.63, 95% CI: 1.49-1.78) and a higher risk of lifelong bladder cancer (SHR: 2.72, 95% CI: 1.99-3.71) when compared with those without AE. Our study reveals that unfavorable treatment outcomes of benign prostate hyperplasia, whether caused by medication or surgical treatment, are associated with a higher incidence of bladder cancer. Unfavorable outcomes of surgical treatment are associated with higher risk of geriatric AEs, and unfavorable outcomes of medication treatment are associated with a higher risk of all-cause mortality. FAU - Lin, Yu-Hsiang AU - Lin YH AUID- ORCID: 0000-0001-9923-5747 AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. linyh@cgmh.org.tw. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. linyh@cgmh.org.tw. AD - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. linyh@cgmh.org.tw. FAU - Hou, Chen-Pang AU - Hou CP AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. glucose1979@gmail.com. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. glucose1979@gmail.com. AD - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. glucose1979@gmail.com. FAU - Juang, Horng-Heng AU - Juang HH AUID- ORCID: 0000-0002-8524-8253 AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. hhj143@mail.cgu.edu.tw. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. hhj143@mail.cgu.edu.tw. AD - Department of Anatomy, School of Medicine, Chang Gung University, Kwei-shan, Tao-Yuan 333, Taoyuan, Taiwan, China. hhj143@mail.cgu.edu.tw. FAU - Chang, Phei-Lang AU - Chang PL AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. henryc@cgmh.org.tw. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. henryc@cgmh.org.tw. FAU - Chen, Tien-Hsing AU - Chen TH AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. skyheart0826@gmail.com. AD - Department of Cardiology, Chang Gung Memorial Hospital at Keelung, Biostatiscal consultation center of Chang Gung Memorial hospital, Community Medicine Research Center, Keelung, Keelung 204, Taiwan, China. skyheart0826@gmail.com. FAU - Chen, Chien-Lun AU - Chen CL AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. FAU - Tsui, Ke-Hung AU - Tsui KH AUID- ORCID: 0000-0001-9814-0914 AD - Department of Urology, Chang Gung Memorial Hospital at linkou, Taoyuan 333, Taiwan, China. khtsui@yahoo.com. AD - School of Medicine, Chang Gung University, Taoyuan 333, Taiwan, China. khtsui@yahoo.com. LA - eng GR - CRPG3A1061/Chang Gung Memorial Hospital, Linkou/ PT - Journal Article DEP - 20190927 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC6832159 OTO - NOTNLM OT - benign prostate hyperplasia OT - bladder outlet obstruction OT - diabetes mellitus OT - lower urinary tract symptoms OT - prostatectomy OT - urinary tract infection COIS- The authors declare that they have no competing interests. EDAT- 2019/10/02 06:00 MHDA- 2019/10/02 06:01 PMCR- 2019/09/27 CRDT- 2019/10/02 06:00 PHST- 2019/08/14 00:00 [received] PHST- 2019/09/02 00:00 [revised] PHST- 2019/09/23 00:00 [accepted] PHST- 2019/10/02 06:00 [entrez] PHST- 2019/10/02 06:00 [pubmed] PHST- 2019/10/02 06:01 [medline] PHST- 2019/09/27 00:00 [pmc-release] AID - jcm8101550 [pii] AID - jcm-08-01550 [pii] AID - 10.3390/jcm8101550 [doi] PST - epublish SO - J Clin Med. 2019 Sep 27;8(10):1550. doi: 10.3390/jcm8101550.