PMID- 31570117
OWN - NLM
STAT- MEDLINE
DCOM- 20200320
LR  - 20231014
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 8
DP  - 2019 Oct 1
TI  - Functional brain alterations following mild-to-moderate sensorineural hearing 
      loss in children.
LID - 10.7554/eLife.46965 [doi]
LID - e46965
AB  - Auditory deprivation in the form of deafness during development leads to lasting 
      changes in central auditory system function. However, less is known about the 
      effects of mild-to-moderate sensorineural hearing loss (MMHL) during development. 
      Here, we used a longitudinal design to examine late auditory evoked responses and 
      mismatch responses to nonspeech and speech sounds for children with MMHL. At Time 
      1, younger children with MMHL (8-12 years; n = 23) showed age-appropriate 
      mismatch negativities (MMNs) to sounds, but older children (12-16 years; n = 23) 
      did not. Six years later, we re-tested a subset of the younger (now older) 
      children with MMHL (n = 13). Children who had shown significant MMNs at Time 1 
      showed MMNs that were reduced and, for nonspeech, absent at Time 2. Our findings 
      demonstrate that even a mild-to-moderate hearing loss during early-to-mid 
      childhood can lead to changes in the neural processing of sounds in late 
      childhood/adolescence.
CI  - (c) 2019, Calcus et al.
FAU - Calcus, Axelle
AU  - Calcus A
AUID- ORCID: 0000-0002-1240-1122
AD  - Laboratoire des Systemes Perceptifs, Departement d'Etudes Cognitives, Ecole 
      Normale Superieure, PSL University, CNRS, Paris, France.
AD  - Department of Speech, Hearing and Phonetic Sciences, University College London, 
      London, United Kingdom.
FAU - Tuomainen, Outi
AU  - Tuomainen O
AD  - Department of Speech, Hearing and Phonetic Sciences, University College London, 
      London, United Kingdom.
FAU - Campos, Ana
AU  - Campos A
AD  - Department of Speech, Hearing and Phonetic Sciences, University College London, 
      London, United Kingdom.
FAU - Rosen, Stuart
AU  - Rosen S
AD  - Department of Speech, Hearing and Phonetic Sciences, University College London, 
      London, United Kingdom.
FAU - Halliday, Lorna F
AU  - Halliday LF
AUID- ORCID: 0000-0003-1883-7741
AD  - Department of Speech, Hearing and Phonetic Sciences, University College London, 
      London, United Kingdom.
AD  - MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United 
      Kingdom.
LA  - eng
GR  - FP7-607139/H2020 Marie Sklodowska-Curie Actions/International
GR  - RES-061-25-0440/ESRC/International
GR  - RES-061-25-0440/ESRC National Centre for Research Methods, University of 
      Southampton/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191001
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
SB  - IM
MH  - Adolescent
MH  - *Auditory Perception
MH  - Brain Diseases/*physiopathology
MH  - Child
MH  - Child Development
MH  - Child, Preschool
MH  - Evoked Potentials, Auditory
MH  - Female
MH  - Hearing Loss, Sensorineural/*complications
MH  - Humans
MH  - Infant
MH  - Longitudinal Studies
MH  - Male
PMC - PMC6828531
OTO - NOTNLM
OT  - LAER
OT  - MMN
OT  - auditory
OT  - development
OT  - hearing loss
OT  - human
OT  - neuroscience
COIS- AC, OT, AC, SR, LH No competing interests declared
EDAT- 2019/10/02 06:00
MHDA- 2020/03/21 06:00
PMCR- 2019/10/01
CRDT- 2019/10/02 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/09/07 00:00 [accepted]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2020/03/21 06:00 [medline]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/01 00:00 [pmc-release]
AID - 46965 [pii]
AID - 10.7554/eLife.46965 [doi]
PST - epublish
SO  - Elife. 2019 Oct 1;8:e46965. doi: 10.7554/eLife.46965.