PMID- 31571008
OWN - NLM
STAT- MEDLINE
DCOM- 20200817
LR  - 20200817
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 126
IP  - 12
DP  - 2019 Dec
TI  - Association of daily physical activity with cognition and mood disorders in 
      treatment-naive patients with early-stage Parkinson's disease.
PG  - 1617-1624
LID - 10.1007/s00702-019-02085-x [doi]
AB  - To determine the association of daily physical activity with cognition, mood 
      disorders, and olfactory function in treatment-naive patients with early-stage 
      Parkinson's disease (PD). The study subjects were 52 treatment-naive patients 
      with early-stage PD (< 80 years). Daily physical activity was measured using a 
      wearable sensor with a built-in triaxial accelerometer, and its association with 
      cognition [mini-mental state examination (MMSE), clock-drawing test (CDT), 
      frontal assessment battery (FAB), and behavioral assessment of the dysexecutive 
      syndrome (BADS)], depressive symptoms [Beck Depression Inventory-Second Edition 
      (BDI-II)], apathy [Starkstein Apathy Scale (AS)], and olfactory function [Odor 
      Stick Identification Test for the Japanese (OSIT-J)] was analyzed using multiple 
      linear regression after adjustment for age, sex, and education status. The daily 
      physical activity (0.42 +/- 0.11 m/s(2)) of the PD group was significantly lower 
      than that of healthy controls (p < 0.001). Moreover, the daily physical activity 
      of the PD group was significantly associated with FAB (beta = 0.337, p = 0.027) and 
      BADS (beta = 0.374, p = 0.017) scores, but not with MMSE, CDT, BDI-II, AS, and 
      OSIT-J scores. The daily physical activity is significantly reduced in 
      treatment-naive patients with early-stage PD, and the low activity correlates 
      with frontal/executive function.
FAU - Terashi, Hiroo
AU  - Terashi H
AUID- ORCID: 0000-0001-5465-557X
AD  - Department of Neurology, Tokyo Medical University, 6-7-1 Nishishinjuku, 
      Shinjuku-ku, Tokyo, 160-0023, Japan. terashi@tokyo-med.ac.jp.
FAU - Taguchi, Takeshi
AU  - Taguchi T
AD  - Department of Neurology, Tokyo Medical University, 6-7-1 Nishishinjuku, 
      Shinjuku-ku, Tokyo, 160-0023, Japan.
FAU - Ueta, Yuki
AU  - Ueta Y
AD  - Department of Neurology, Tokyo Medical University, 6-7-1 Nishishinjuku, 
      Shinjuku-ku, Tokyo, 160-0023, Japan.
FAU - Mitoma, Hiroshi
AU  - Mitoma H
AD  - Medical Education Promotion Center, Tokyo Medical University, 6-7-1 
      Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
FAU - Aizawa, Hitoshi
AU  - Aizawa H
AD  - Department of Neurology, Tokyo Medical University, 6-7-1 Nishishinjuku, 
      Shinjuku-ku, Tokyo, 160-0023, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190930
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Accelerometry
MH  - Aged
MH  - *Cognition
MH  - *Exercise/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/*etiology
MH  - Parkinson Disease/*complications/*psychology
MH  - Wearable Electronic Devices
OTO - NOTNLM
OT  - Cognition
OT  - Daily physical activity
OT  - Mood disorder
OT  - Olfaction
OT  - Parkinson's disease
EDAT- 2019/10/02 06:00
MHDA- 2020/08/18 06:00
CRDT- 2019/10/02 06:00
PHST- 2019/06/03 00:00 [received]
PHST- 2019/09/17 00:00 [accepted]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2020/08/18 06:00 [medline]
PHST- 2019/10/02 06:00 [entrez]
AID - 10.1007/s00702-019-02085-x [pii]
AID - 10.1007/s00702-019-02085-x [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2019 Dec;126(12):1617-1624. doi: 
      10.1007/s00702-019-02085-x. Epub 2019 Sep 30.