PMID- 31571723
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200401
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 83
IP  - 4
DP  - 2019 Oct
TI  - Effectiveness of a commercial porcine reproductive and respiratory syndrome virus 
      (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in 
      late-term pregnant gilts.
PG  - 248-254
AB  - The objective of the present study was to evaluate the efficacy of a commercial 
      porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine 
      against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts. 
      Gilts were vaccinated intramuscularly 56 and 35 days antepartum (on days 58 and 
      79 of gestation) and challenged intranasally 21 days antepartum (on day 93 of 
      gestation) with PRRSV-1 or PRRSV-2. Regardless of the challenge strain's 
      genotype, the vaccinated gilts carried their pregnancies to term and farrowed 
      between days 114 and 115 of gestation. All the unvaccinated gilts aborted, 
      between days 105 and 110 of gestation. The vaccinated gilts had a significantly 
      lower level (P < 0.05) of PRRSV viremia and significantly higher levels (P < 
      0.05) of virus-neutralizing antibodies and interferon-gamma-secreting cells compared 
      with the unvaccinated gilts. The mean number of PRRSV-positive cells per area of 
      fetal tissue examined did not differ significantly between the litters from the 
      vaccinated and unvaccinated gilts. The data presented here indicate that 
      vaccination in late-term pregnancy with PRRSV subunit vaccine is efficacious 
      against reproductive failure due to heterologous PRRSV-1 and PRRSV-2 infection.
CI  - Copyright and/or publishing rights held by the Canadian Veterinary Medical 
      Association.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Kim, Hanjin
AU  - Kim H
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Protein Subunits)
RN  - 0 (Vaccines, Subunit)
RN  - 0 (Viral Proteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Female
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*classification/immunology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/prevention & control/*veterinary
MH  - Protein Subunits
MH  - Swine
MH  - Vaccines, Subunit/immunology
MH  - Viral Proteins/immunology
MH  - Viral Vaccines/*immunology
PMC - PMC6753889
EDAT- 2019/10/02 06:00
MHDA- 2020/01/07 06:00
PMCR- 2020/04/01
CRDT- 2019/10/02 06:00
PHST- 2018/11/04 00:00 [received]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - cjvr_04_248 [pii]
PST - ppublish
SO  - Can J Vet Res. 2019 Oct;83(4):248-254.