PMID- 31571739
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0971-4065 (Print)
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Linking)
VI  - 29
IP  - 5
DP  - 2019 Sep-Oct
TI  - Impact of Angiotensin-converting Enzyme and Matrix Metalloproteinase-3 Gene 
      Polymorphisms on Risk for Developing Vascular Access Failure in Hemodialysis 
      Patients - A Pilot Study.
PG  - 329-333
LID - 10.4103/ijn.IJN_303_18 [doi]
AB  - For adequate hemodialysis, functional vascular access is obligatory. Neointimal 
      hyperplasia (NIH) has a central role in stenosis and thrombosis development, 
      which represent the most frequent causes of vascular access failure. Polymorphism 
      of different genes that have a significant role in endothelial function may have 
      an impact on NIH development. Therefore, the aim of our study is to determine the 
      effect of angiotensin-converting enzyme (ACE) I/D and matrix metalloproteinase-3 
      (MMP3) 5A/6A polymorphism on risk for developing vascular access failure in 
      hemodialysis patients. The study included 200 patients on regular hemodialysis at 
      Nephrology Department, University Medical Center Zvezdara. Retrospective analysis 
      included a collection of general and vascular access data from medical records. 
      Genetic analysis was performed by using polymerase chain reaction-restriction 
      fragment length polymorphism method (PCR-RFLP). Patients were divided into two 
      groups: Group 1-patients who have never experienced vascular access failure and 
      Group 2-patients who have at least one spontaneous vascular access failure. There 
      was no difference in age, gender, hemodialysis vintage, main diagnosis, presence 
      of hypertension, and diabetes mellitus between the two groups. There were no 
      statistically significant differences in the frequencies of ACE and MMP3 
      genotypes between the two groups. Without statistical significance, it was found 
      that homozygotes for I allele had two times higher risk for developing vascular 
      access failure than homozygotes for D allele (OR 2.00; 95%CI: 0.727-5.503; P = 
      0.180). In addition, patients with 5A allele have 1.7 times higher risk for 
      developing vascular access failure compared with patients without this allele (OR 
      1.745; 95% CI: 0.868-3.507; P = 0.118). Patients with vascular access failure do 
      not have different genotype distribution regarding ACE gene and MMP3 gene 
      polymorphism as compared with patients without vascular access failure. Still, 
      homozygotes for I allele and homozygotes for 5A allele have higher risk for 
      developing vascular access failure compared with other patients.
CI  - Copyright: (c) 2019 Indian Journal of Nephrology.
FAU - Jankovic, Aleksandar
AU  - Jankovic A
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Tosic, Jelena
AU  - Tosic J
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Buzadzic, Ivana
AU  - Buzadzic I
AD  - Department of Human Genetics and Prenatal Diagnostics, University Medical Center 
      Zvezdara, Belgrade, Serbia.
FAU - Djuric, Petar
AU  - Djuric P
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Bulatovic, Ana
AU  - Bulatovic A
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Markovic, Dragana
AU  - Markovic D
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Popovic, Jovan
AU  - Popovic J
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
FAU - Dimkovic, Nada
AU  - Dimkovic N
AD  - Department of Nephrology with Dialysis, University Medical Center Zvezdara, 
      Belgrade, Serbia.
AD  - Department of Medical Faculty, University of Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC6755919
OTO - NOTNLM
OT  - Angiotensin-converting enzyme gene polymorphism
OT  - failure
OT  - matrix metalloproteinase-3 gene polymorphism
OT  - vascular access
COIS- There are no conflicts of interest.
EDAT- 2019/10/02 06:00
MHDA- 2019/10/02 06:01
PMCR- 2019/09/01
CRDT- 2019/10/02 06:00
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2019/10/02 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - IJN-29-329 [pii]
AID - 10.4103/ijn.IJN_303_18 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2019 Sep-Oct;29(5):329-333. doi: 10.4103/ijn.IJN_303_18.