PMID- 31572200
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 10
DP  - 2019
TI  - Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts 
      Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway.
PG  - 1034
LID - 10.3389/fphar.2019.01034 [doi]
LID - 1034
AB  - Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal 
      medicine, has been traditionally prescribed in China and other countries to treat 
      affective disorders. The medicinal parts of ginseng, the roots and flower buds, 
      have become increasingly popular as dietary supplements due to the current 
      holistic healthcare trend. We have investigated for the first time the 
      antidepressive actions of the different medicinal parts, namely, the main roots, 
      fibrous roots, and flower buds (in water extract and powder), of 
      garden-cultivated ginseng through behavioral and drug-induced tests in mice. The 
      water extracts, but not the powders of ginseng fibrous roots, flower buds, and 
      main roots (1.5 g of crude drug per kilogram, p.o.), significantly reduced the 
      immobility time in the forced swim test (FST) and tail suspension test (TST); 
      moreover, the water extracts enhanced the 5-hydroxytryptophan (5-HTP)-induced 
      head-twitch response and antagonized the action of reserpine in the mouse. We 
      then explored the antidepressive mechanism of action of the ginsenoside Rb1 (Rb1) 
      related to the brain-derived neurotrophic factor (BDNF) and its downstream 
      proteins in mice exposed to chronic unpredictable mild stress (CUMS). Treatment 
      with Rb1 (20 mg/kg, p.o.) for 21 days significantly attenuated the CUMS-induced 
      decrease in the activities of BDNF, tropomyosin-related kinase B (TrkB), protein 
      kinase B (AKT), extracellular regulatory protein kinase (ERK), and cyclic 
      adenosine monophosphate (cAMP) response element binding protein (CREB) in the 
      mouse hippocampal CA3 region and prefrontal cortex (PFC). Interestingly, 
      treatment with the novel TrkB antagonist ANA-12 (0.5 mg/kg, i.p.) did not alter 
      the level of BDNF but significantly blocked the antidepressive effects of Rb1 on 
      proteins downstream of BDNF in CUMS-treated mice. These results suggest that 
      BDNF-TrkB-CREB signaling may be involved in the antidepressive mechanism of the 
      action of Rb1.
CI  - Copyright (c) 2019 Wang, Lei, Tian, Wang, Zhang and Zhang.
FAU - Wang, Guoli
AU  - Wang G
AD  - College of Pharmacy, Jinan University, Guangzhou, China.
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 
      China.
FAU - Lei, Cong
AU  - Lei C
AD  - College of Pharmacy, Jinan University, Guangzhou, China.
FAU - Tian, Ya
AU  - Tian Y
AD  - College of Pharmacy, Jinan University, Guangzhou, China.
FAU - Wang, Yingping
AU  - Wang Y
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 
      China.
FAU - Zhang, Lianxue
AU  - Zhang L
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 
      China.
FAU - Zhang, Ronghua
AU  - Zhang R
AD  - College of Pharmacy, Jinan University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20190913
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6753202
OTO - NOTNLM
OT  - BDNF-TrkB-CREB signaling
OT  - antidepressive effects
OT  - chronic unpredictable mild stress
OT  - fibrous roots
OT  - flower buds
OT  - ginseng
OT  - ginsenoside Rb1
OT  - main roots
EDAT- 2019/10/02 06:00
MHDA- 2019/10/02 06:01
PMCR- 2019/09/13
CRDT- 2019/10/02 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/08/14 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2019/10/02 06:01 [medline]
PHST- 2019/09/13 00:00 [pmc-release]
AID - 10.3389/fphar.2019.01034 [doi]
PST - epublish
SO  - Front Pharmacol. 2019 Sep 13;10:1034. doi: 10.3389/fphar.2019.01034. eCollection 
      2019.