PMID- 31572230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 10
DP  - 2019
TI  - Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD).
PG  - 612
LID - 10.3389/fpsyt.2019.00612 [doi]
LID - 612
AB  - Autism spectrum disorder (ASD) is a behaviorally defined disorder that is now 
      thought to affect approximately 1 in 69 children in the United States. In most 
      cases, the etiology is unknown, but several studies point to the interaction of 
      genetic predisposition with environmental factors. The immune system is thought 
      to have a causative role in ASD, and specific studies have implicated T 
      lymphocytes, monocytes, natural killer (NK) cells, and certain cytokines. The 
      human leukocyte antigen (HLA) system is involved in the underlying process for 
      shaping an individual's immune system, and specific HLA alleles are associated 
      with specific diseases as risk factors. In this study, we determine whether a 
      specific HLA allele was associated with ASD in a large cohort of patients with 
      ASD. Identifying such an association could help in the identification of immune 
      system components which may have a causative role in specific cohorts of patients 
      with ASD who share similar specific clinical features. Specimens from 143 
      patients with ASD were analyzed with respect to race and ethnicity. Overall, 
      HLA-Cw7 was present in a much greater frequency than expected in individuals with 
      ASD as compared to the general population. Further, the cohort of patients who 
      express HLA-Cw7 shares specific immune system/inflammatory clinical features 
      including being more likely to have allergies, food intolerances, and chronic 
      sinusitis as compared to those with ASD who did not express HLA-Cw7. HLA-Cw7 has 
      a role in stimulating NK cells. Thus, this finding may indicate that chronic 
      over-activation of NK cells may have a role in the manifestation of ASD in a 
      cohort of patients with increased immune system/inflammatory features.
CI  - Copyright (c) 2019 Harville, Rhodes-Clark, Bennuri, Delhey, Slattery, Tippett, 
      Wynne, Rose, Kahler and Frye.
FAU - Harville, Terry
AU  - Harville T
AD  - Department of Pathology, University of Arkansas for Medical Sciences, Little 
      Rock, AR, United States.
AD  - Department of Internal Medicine, University of Arkansas for Medical Sciences, 
      Little Rock, AR, United States.
FAU - Rhodes-Clark, Bobbie
AU  - Rhodes-Clark B
AD  - Department of Pathology, University of Arkansas for Medical Sciences, Little 
      Rock, AR, United States.
FAU - Bennuri, Sirish C
AU  - Bennuri SC
AD  - Department of Pediatrics, College of Medicine, University of Arkansas for Medical 
      Sciences, Little Rock, AR, United States.
AD  - Arkansas Children's Research Institute, Little Rock, AR, United States.
FAU - Delhey, Leanna
AU  - Delhey L
AD  - School of Public Health, University of Arkansas for Medical Sciences, Little 
      Rock, AR, United States.
AD  - Arkansas Children's Research Institute, Little Rock, AR, United States.
FAU - Slattery, John
AU  - Slattery J
AD  - BioRosa Technologies Inc, San Francisco, CA, United States.
FAU - Tippett, Marie
AU  - Tippett M
AD  - Department of Pediatrics, College of Medicine, University of Arkansas for Medical 
      Sciences, Little Rock, AR, United States.
AD  - Arkansas Children's Research Institute, Little Rock, AR, United States.
FAU - Wynne, Rebecca
AU  - Wynne R
AD  - National Center for Toxicological Research, Jefferson, AR, United States.
FAU - Rose, Shannon
AU  - Rose S
AD  - Department of Pediatrics, College of Medicine, University of Arkansas for Medical 
      Sciences, Little Rock, AR, United States.
AD  - Arkansas Children's Research Institute, Little Rock, AR, United States.
FAU - Kahler, Stephen
AU  - Kahler S
AD  - Department of Pediatrics, College of Medicine, University of Arkansas for Medical 
      Sciences, Little Rock, AR, United States.
AD  - Arkansas Children's Research Institute, Little Rock, AR, United States.
FAU - Frye, Richard E
AU  - Frye RE
AD  - Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, United 
      States.
AD  - Department of Child Health, University of Arizona College of Medicine, Phoenix, 
      AZ, United States.
LA  - eng
PT  - Journal Article
DEP - 20190911
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6749146
OTO - NOTNLM
OT  - HLA
OT  - autism (ASD)
OT  - immune system
OT  - innate immnuity
OT  - natural killer cells
EDAT- 2019/10/02 06:00
MHDA- 2019/10/02 06:01
PMCR- 2019/09/11
CRDT- 2019/10/02 06:00
PHST- 2018/12/18 00:00 [received]
PHST- 2019/07/31 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2019/10/02 06:01 [medline]
PHST- 2019/09/11 00:00 [pmc-release]
AID - 10.3389/fpsyt.2019.00612 [doi]
PST - epublish
SO  - Front Psychiatry. 2019 Sep 11;10:612. doi: 10.3389/fpsyt.2019.00612. eCollection 
      2019.