PMID- 31572548
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 18
IP  - 4
DP  - 2019 Oct
TI  - Higher proportion of low-virulence anaerobic bacterial infection in young 
      patients with intervertebral disc herniation.
PG  - 3085-3089
LID - 10.3892/etm.2019.7910 [doi]
AB  - Intervertebral disc (IVD) degeneration caused by the latent infection of 
      low-virulence anaerobic bacteria (LVAB) is a hot research topic. The present 
      study analyzed and compared the positive rate of LVAB within IVDs of patients of 
      different ages. IVD samples were intraoperatively retrieved from 176zpatients 
      with disc herniation and subjected to microbiological culture. Subsequently, all 
      the patients were classified into 3 groups based on their ages as follows: Group 
      A (age <30 years), group B (age from 30 to 50 years) and group C (age >50 years) 
      and the positive rates of LVAB were compared among the three groups. The severity 
      of IVD degeneration was also assessed by measuring intervertebral height. Of the 
      176 cultured discs, 39 samples had bacterial growth, while 6 of them were 
      suspiciously contaminated. Follwoing the exclusion of the 6 suspicious samples, 
      31 samples were Propionibacterium acnes and 2 samples were coagulase-negative 
      Staphylococci of the remaining 33 samples, The bacterial positive rates were 
      significantly higher in younger patients, with 34.4% (11/32), 25.5% (13/51) and 
      10.3% (9/87) in group A, B and C, respectively. More importantly, the 
      bacterial-positive samples had a significantly lower disc height compared with 
      the negative samples in groups A and B. Therefore, it can be reasonably concluded 
      that younger patients have a much higher prevalence of LVAB infection in 
      herniated IVDs and a greater severity of IVD degeneration when infected by 
      bacteria. The LVAB may have a strong association with IVD degeneration, 
      particularly in young patients.
CI  - Copyright: (c) Tang et al.
FAU - Tang, Guoqing
AU  - Tang G
AD  - Orthopedic Center, The First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, P.R. China.
AD  - Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, 
      Jiangsu 215300, P.R. China.
FAU - Chen, Yong
AU  - Chen Y
AD  - Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, 
      Jiangsu 215300, P.R. China.
AD  - Department of Orthopaedics, The Second Hospital Affiliated to Soochow University, 
      Suzhou, Jiangsu 215008, P.R. China.
FAU - Chen, Ji
AU  - Chen J
AD  - Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, 
      Jiangsu 215300, P.R. China.
FAU - Wang, Zhuo
AU  - Wang Z
AD  - Orthopedic Center, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, 
      Jiangsu 215300, P.R. China.
FAU - Jiang, Weimin
AU  - Jiang W
AD  - Orthopedic Center, The First Affiliated Hospital of Soochow University, Suzhou, 
      Jiangsu 215000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190816
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6755454
OTO - NOTNLM
OT  - Propionibacterium acnes
OT  - coagulase-negative Staphylococci
OT  - disc herniation
OT  - low-virulence anaerobic bacteria
OT  - young patient
EDAT- 2019/10/02 06:00
MHDA- 2019/10/02 06:01
PMCR- 2019/08/16
CRDT- 2019/10/02 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2019/10/02 06:01 [medline]
PHST- 2019/08/16 00:00 [pmc-release]
AID - ETM-0-0-7910 [pii]
AID - 10.3892/etm.2019.7910 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Oct;18(4):3085-3089. doi: 10.3892/etm.2019.7910. Epub 2019 Aug 
      16.