PMID- 31573322
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20201231
IS  - 1557-8127 (Electronic)
IS  - 1540-658X (Linking)
VI  - 18
IP  - 1
DP  - 2020 Jan
TI  - Single-Molecule Characterization of Drug Delivery Systems.
PG  - 56-63
LID - 10.1089/adt.2018.903 [doi]
AB  - Delivery of the drug to a desired point of body and controlled release of the 
      therapeutic agent are important features, provided by drug delivery systems 
      (DDSs), for development of today's effective medicines. A variety of 
      nanomaterials or nanomolecules such as lipids/liposomes, nucleic acids, 
      peptides/proteins, composites, polymers, or carbon nanotubes can be used as DDSs. 
      Single-molecule characterization of these small materials in terms of their size, 
      shape, surface, encapsulation efficiency, as well as interaction with the 
      drug-receiving cell has importance for their efficiency. The loading, 
      distribution, or leakage of the drug as well as its interaction with DDS should 
      also be characterized. Although diverse techniques are present for 
      characterization of specific DDS material, methods such as electron microscopy 
      and fluorescence microscopy are widely used. In this review, the current 
      methodologies utilized for the single-molecule characterization of mostly 
      preferred DDS materials were presented.
FAU - Okay, Sezer
AU  - Okay S
AD  - Department of Vaccine Technology, Vaccine Institute, Hacettepe University, 
      Ankara, Turkey.
AD  - Department of Biology, Faculty of Science, Cankiri Karatekin University, Cankiri, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191001
PL  - United States
TA  - Assay Drug Dev Technol
JT  - Assay and drug development technologies
JID - 101151468
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Nanostructures/*chemistry
MH  - Particle Size
MH  - Pharmaceutical Preparations/*chemistry
MH  - Surface Properties
OTO - NOTNLM
OT  - drug delivery system
OT  - nanomaterial
OT  - nanomolecule
OT  - nanotechnology
OT  - single-molecule
EDAT- 2019/10/02 06:00
MHDA- 2021/01/01 06:00
CRDT- 2019/10/02 06:00
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2019/10/02 06:00 [entrez]
AID - 10.1089/adt.2018.903 [doi]
PST - ppublish
SO  - Assay Drug Dev Technol. 2020 Jan;18(1):56-63. doi: 10.1089/adt.2018.903. Epub 
      2019 Oct 1.