PMID- 31574083
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 10
DP  - 2019
TI  - The neural substrate of self- and other-concerned wellbeing: An fMRI study.
PG  - e0203974
LID - 10.1371/journal.pone.0203974 [doi]
LID - e0203974
AB  - Happiness, or Subjective Well-Being (SWB), is generally considered as a peaceful 
      and satisfied state accompanied by consistent and optimistic mood. Due to its 
      subjective and elusive nature, however, wellbeing has only been scarcely 
      investigated in the neuroimaging literature. In this study, we investigated its 
      neural substrates by characterizing two different perspectives: self- or 
      other-concerned wellbeing. In the present study, 22 participants evaluated the 
      subjective happiness (with button presses 1 to 4) to 3 categories (intra- and 
      inter-personal and neutral) of pre-rated pictures in a slow event-related fMRI. 
      Because wellbeing is constantly featured by pleasure feelings after 
      self-inspection, we predict that happier conditions, featured by "intra-personal 
      vs. neutral" and "inter-personal vs. neutral" conditions, should yield higher 
      BOLD activities in overlapping reward- and self-related regions. Indeed, medial 
      prefrontal (mPFC), pregenual ACC (pACC), precuneus and posterior cingulate cortex 
      (PCC) were revealed both by General Linear Model (GLM) (categorical contrasts) 
      and parametric modulations (correlations with rating 1-4s), specifically, more 
      connectivity between nucleus accumbens (NAcc) and mPFC, via additional 
      psychophysiological interaction, or PPI, analyses. More interestingly, GLM and 
      multivariate searchlight analyses jointly reveal the subdivision of mPFC and the 
      PCC/precuneus, with anterior mPFC and dorsal PCC/precuneus more for 
      interpersonal, posterior mPFC and ventral PCC/precuneus more for intrapersonal, 
      SWB, respectively. Taken together, these results are not only consistent with the 
      "cortical midline hypothesis of the self", but also extending the "spatial 
      gradients of self-to-other-concerned processing" from mPFC to including both mPFC 
      and PCC/precuneus, making them two "hubs" of self-to-other-concerned wellbeing 
      network.
FAU - Jo, HanShin
AU  - Jo H
AD  - Dept. of Psychology, National Cheng Kung University (NCKU), Tainan, Taiwan.
AD  - Inst. Of Medical Informatics, NCKU, Tainan, Taiwan.
FAU - Ou, Yang-Yen
AU  - Ou YY
AUID- ORCID: 0000-0001-6490-9545
AD  - Dept. of Electrical Engineering, NCKU, Tainan, Taiwan.
FAU - Kung, Chun-Chia
AU  - Kung CC
AUID- ORCID: 0000-0002-4362-7837
AD  - Dept. of Psychology, National Cheng Kung University (NCKU), Tainan, Taiwan.
AD  - Mind Research and Imaging (MRI) Center, Tainan, Taiwan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191001
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Female
MH  - *Gyrus Cinguli/diagnostic imaging/physiology
MH  - *Happiness
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - *Neural Pathways/diagnostic imaging/physiology
MH  - Psychophysiology
PMC - PMC6772049
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/10/02 06:00
MHDA- 2020/03/10 06:00
PMCR- 2019/10/01
CRDT- 2019/10/02 06:00
PHST- 2018/08/28 00:00 [received]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/10/02 06:00 [entrez]
PHST- 2019/10/02 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - PONE-D-18-25056 [pii]
AID - 10.1371/journal.pone.0203974 [doi]
PST - epublish
SO  - PLoS One. 2019 Oct 1;14(10):e0203974. doi: 10.1371/journal.pone.0203974. 
      eCollection 2019.