PMID- 31574846
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 39
DP  - 2019 Sep
TI  - Mechanisms of action of molecules with anti-TNF-alpha activity on intestinal 
      barrier inflammation: A systematic review protocol.
PG  - e17285
LID - 10.1097/MD.0000000000017285 [doi]
LID - e17285
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), among cytokines that mediate 
      the inflammatory process, plays an important role in diseases involving the loss 
      of intestinal barrier integrity. Several molecules with anti-TNF-alpha activity 
      have been studied aiming to develop new therapies. The purpose of this paper is 
      to describe the systematic review protocol of experimental studies that determine 
      mechanisms of action of molecules with anti-TNF-alpha activity on intestinal 
      barrier inflammation. METHODS: This protocol is guided by the Preferred Reporting 
      Items for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P). The 
      databases to be searched are PubMed, EMBASE, Scopus, ScienceDirect, and Web of 
      Science. Experimental studies in rats or mice that assessed the activity of 
      anti-TNF-alpha molecules in models of intestinal barrier inflammation will be 
      included in the systematic review. Studies characteristics, experimental model, 
      and main results will be described and the bias risk assessment will be 
      performed. Two independent reviewers will perform study selection, data 
      extraction, and methodological quality assessment. A narrative synthesis will be 
      made for the included studies. Also, if sufficient data is available, a 
      meta-analysis will be conducted. I statistics will be used to assess 
      heterogeneity. RESULTS: The present protocol will assist in producing a 
      systematic review that identifies the mechanisms underlying the reduction of 
      TNF-alpha in intestinal barrier inflammation models. CONCLUSION: The systematic 
      review may contribute to the theoretical basis of research on new molecules with 
      anti-TNF-alpha potential and, consequently, in the development of new therapies 
      employed in humans. PROSPERO REGISTRATION NUMBER: CRD42019131862.
FAU - Lima, Mayara Santa Rosa
AU  - Lima MSR
AD  - Biochemistry Postgraduate Program, Biosciences Center.
FAU - Lima, Vanessa Cristina Oliveira de
AU  - Lima VCO
AD  - Biochemistry Postgraduate Program, Biosciences Center.
FAU - Piuvezam, Grasiela
AU  - Piuvezam G
AD  - Collective Health Postgraduate Program (PPGSCoL).
FAU - Azevedo, Kesley Pablo Morais de
AU  - Azevedo KPM
AD  - Collective Health Postgraduate Program (PPGSCoL).
FAU - Maciel, Bruna Leal Lima
AU  - Maciel BLL
AD  - Nutrition Postgraduate Program, Center for Health Sciences, Federal University of 
      Rio Grande do Norte, Natal, RN, Brazil.
FAU - Morais, Ana Heloneida de Araujo
AU  - Morais AHA
AD  - Biochemistry Postgraduate Program, Biosciences Center.
AD  - Nutrition Postgraduate Program, Center for Health Sciences, Federal University of 
      Rio Grande do Norte, Natal, RN, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Gastrointestinal Agents/*pharmacology
MH  - Humans
MH  - Inflammation
MH  - Intestinal Mucosa/*drug effects
MH  - Research Design
MH  - Systematic Reviews as Topic
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/*drug effects
PMC - PMC6775351
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/10/03 06:00
MHDA- 2019/10/15 06:00
PMCR- 2019/09/27
CRDT- 2019/10/03 06:00
PHST- 2019/10/03 06:00 [entrez]
PHST- 2019/10/03 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2019/09/27 00:00 [pmc-release]
AID - 00005792-201909270-00055 [pii]
AID - MD-D-19-06745 [pii]
AID - 10.1097/MD.0000000000017285 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Sep;98(39):e17285. doi: 10.1097/MD.0000000000017285.