PMID- 31575010
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20200227
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 17
IP  - 10
DP  - 2019 Sep 30
TI  - Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived 
      Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates.
LID - 10.3390/md17100564 [doi]
LID - 564
AB  - Chlorophenols (CPs) are environmental pollutants that are produced through 
      various anthropogenic activities and introduced in the environment. Living 
      organisms, including humans, are exposed to these toxic xenobiotics and suffer 
      from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is 
      released in high amounts in the environment and has been listed as a priority 
      pollutant by the US Environmental Protection Agency. Bioremediation has been 
      proposed as a sustainable alternative to conventional remediation methods for the 
      detoxification of phenolic compounds. In this work, we studied the potential of 
      fungal strains isolated as symbionts of marine invertebrates from the 
      underexplored mesophotic coral ecosystems. Hence, the unspecific metabolic 
      pathways of these fungal strains are being explored in the present study, using 
      the powerful analytical capabilities of a UHPLC-HRMS/MS. The newly identified 
      2,4-DCP metabolites add significantly to the knowledge of the transformation of 
      such pollutants by fungi, since such reports are scarce.
FAU - Nikolaivits, Efstratios
AU  - Nikolaivits E
AUID- ORCID: 0000-0002-8022-9272
AD  - Industrial Biotechnology & Biocatalysis Group, Biotechnology Laboratory, School 
      of Chemical Engineering, National Technical University of Athens, 15780 Athens, 
      Greece. snikolai@central.ntua.gr.
FAU - Agrafiotis, Andreas
AU  - Agrafiotis A
AD  - Industrial Biotechnology & Biocatalysis Group, Biotechnology Laboratory, School 
      of Chemical Engineering, National Technical University of Athens, 15780 Athens, 
      Greece. agrafiotisandreas.vep@gmail.com.
FAU - Termentzi, Aikaterini
AU  - Termentzi A
AD  - Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological 
      Institute, 14561 Kifissia, Greece. a.termentzi@bpi.gr.
FAU - Machera, Kyriaki
AU  - Machera K
AD  - Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological 
      Institute, 14561 Kifissia, Greece. k.machera@bpi.gr.
FAU - Le Goff, Geraldine
AU  - Le Goff G
AD  - Institut de Chimie des Substances Naturelles, ICSN, Centre National de la 
      Recherche Scientifique CNRS, 91198 Gif sur Yvette, France.
FAU - Alvarez, Pedro
AU  - Alvarez P
AD  - iMare Natural S.L., 18600 Granada, Spain. pedro.imare@gmail.com.
FAU - Chavanich, Suchana
AU  - Chavanich S
AD  - Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. 
      suchana.c@chula.ac.th.
FAU - Benayahu, Yehuda
AU  - Benayahu Y
AD  - Department of Zoology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 
      69978, Israel. yehudab@tauex.tau.ac.il.
FAU - Ouazzani, Jamal
AU  - Ouazzani J
AUID- ORCID: 0000-0003-4483-6638
AD  - Institut de Chimie des Substances Naturelles, ICSN, Centre National de la 
      Recherche Scientifique CNRS, 91198 Gif sur Yvette, France. 
      jamal.ouazzani@cnrs.fr.
FAU - Fokialakis, Nikolas
AU  - Fokialakis N
AUID- ORCID: 0000-0001-7028-1870
AD  - Division of Pharmacognosy and Chemistry of Natural Products, Department of 
      Pharmacy, University of Athens, 15771 Athens, Greece. fokialakis@pharm.uoa.gr.
FAU - Topakas, Evangelos
AU  - Topakas E
AUID- ORCID: 0000-0003-0078-5904
AD  - Industrial Biotechnology & Biocatalysis Group, Biotechnology Laboratory, School 
      of Chemical Engineering, National Technical University of Athens, 15780 Athens, 
      Greece. vtopakas@chemeng.ntua.gr.
LA  - eng
GR  - 634674/Horizon 2020/
GR  - MIS-5000432/State Scholarships Foundation/
PT  - Journal Article
DEP - 20190930
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Chlorophenols)
RN  - 0 (Phenols)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (Xenobiotics)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Animals
MH  - Anthozoa/metabolism
MH  - Aquatic Organisms/*microbiology
MH  - Biodegradation, Environmental
MH  - Chlorophenols/*metabolism
MH  - Ecosystem
MH  - Fungi/*metabolism
MH  - Humans
MH  - Invertebrates/*microbiology
MH  - Metabolic Networks and Pathways/physiology
MH  - Phenols/metabolism
MH  - Symbiosis/physiology
MH  - Water Pollutants, Chemical/*metabolism
MH  - Xenobiotics/metabolism
PMC - PMC6835501
OTO - NOTNLM
OT  - 2,4-dichlorophenol
OT  - HRMS/MS
OT  - bioremediation
OT  - invertebrate symbionts
OT  - marine-derived fungi
OT  - mesophotic zone
OT  - metabolite analysis
COIS- The authors declare no conflict of interest.
EDAT- 2019/10/03 06:00
MHDA- 2020/02/28 06:00
PMCR- 2019/10/01
CRDT- 2019/10/03 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/09/24 00:00 [revised]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2019/10/03 06:00 [entrez]
PHST- 2019/10/03 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - md17100564 [pii]
AID - marinedrugs-17-00564 [pii]
AID - 10.3390/md17100564 [doi]
PST - epublish
SO  - Mar Drugs. 2019 Sep 30;17(10):564. doi: 10.3390/md17100564.